Results 111 to 120 of about 1,312,492 (269)

iOLE—Human-Centered Software Design for Leakage Detection in Water Distribution Networks

Engineering Proceedings
Leakages in water distribution networks still pose major challenges to water utilities. Despite numerous technological advances, the adoption of digital leakage detection technology remains a slow process.
Ivo Daniel, David Steffelbauer, Ella Steins, Jonas Schorr, Sophie Persigehl, Enrique Campbell, Johannes Koslowski, Jens Kley-Holsteg, Bernd Lindemann, Andrea Cominola   +9 more
doaj   +1 more source

User-Driven Innovation: An Exploratory Study [PDF]

Economic and Business Review, 2015
Despite the relatively robust promotion of user-driven innovation (UDI) in practice, research on UDI remains in its early stages. Following a grounded theory analysis approach, this paper makes a contribution by conducting exploratory research of the ...
Blanka Tacer, Mitja Ruzzier
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

L’Usagent au cœur des réformes de l’enseignement supérieur : vers une pédagogie de « formation par la recherche et avec la société »

Éducation et Socialisation
The text underscores the convergence between universities and social work training institutions towards a “learning by research and with society”, in response to the evolution of a science with society.
Claire Heijboer
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

AI-Driven Cloud Security: Examining the Impact of User Behavior Analysis on Threat Detection

Asian Journal of Research in Computer Science
This study explores the comparative effectiveness of AI-driven user behavior analysis and traditional security measures in cloud computing environments.
S. Olabanji, Yewande Alice Marquis, Chinasa Susan Adigwe, Samson Abidemi Ajayi, Tunbosun Oyewale Oladoyinbo, O. Olaniyi   +5 more
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source