Results 131 to 140 of about 603,022 (311)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Innovative design and evaluation of medical nebulizer for preschool children: A user demand-driven approach.

PLoS ONE
AimsTo enhance the user experience and satisfaction of children's medical nebulizers, and to improve adherence and the efficacy of nebulization treatments for children, this study explores an innovative design and evaluation method for children's medical
YanXiao Zhao, Tao Wang, LiMing Zhang, Basyarah Hamat, Leah Ling Li Pang   +4 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Refinement for user interface designs

, 2008
Formal approaches to software development require that we correctly describe (or specify) systems in order to prove properties about our proposed solution prior to building it. We must then follow a rigorous process to transform our specification into an
Reeves, Steve, Bowen, Judy
core   +1 more source

User-Centered Delivery of AI-Powered Health Care Technologies in Clinical Settings: Mixed Methods Case Study

JMIR Human Factors
BackgroundProviders spend a large percentage of their day using electronic health record (EHR) technology and frequently report frustration when EHR tasks are time-consuming and effortful.
Meredith Schreier, Randall Brandt, Hien Brown, T Saensuksopa, Christine Silva, Laura M Vardoulakis   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A balanced approach to capturing user requirements in business-to-consumer web information systems [PDF]

, 2001
[Abstract]: The development of business-to-consumer web information systems pose special challenges in the requirements analysis phase. It is difficult to capture user requirements given that users are relatively autonomous and anonymous and there are no
Koronios, Andy, Lane, Michael S.
core  

An innovative data mining-driven optimisation modelling approach based on TAM for the design of elderly-centric ICT products

Scientific Reports
To enhance the quality of life and health of the elderly, it is necessary to incorporate their specific needs into the design and manufacturing processes of Information and Communication Technology (ICT) products.
Yu Cao, Xiaogang Yang, Shijian Luo, Kok-Hoong Wong   +3 more
doaj   +1 more source

Marine Sediment Sampling With an Underwater Legged Robot: A User-Driven Sampling Approach for Microplastic Analysis

IEEE Robotics & Automation Magazine
The research was funded by the National Geographic Society under the framework of GOLD (Guardian of the Oceans Legged Drone) project, grant no. NGS 6544 and by the European Commission through the HORIZON-MSCA-2021-PF-01-01 (project number 101061354) and HORIZON-MSCA-2022-PF-01-01 (project number 101108513)
Astolfi, Anna, Chellapurath, Mrudul, Picardi, Giacomo, Capriotti, Martina, Mladinich, Kayla, Laschi, Cecilia, Stefanni, Sergio, Calisti, Marcello, Astolfi, Anna   +8 more
openaire   +2 more sources