Results 81 to 90 of about 1,312,492 (269)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

How personal anticipations and perceived gratifications influence continuous use intention toward AI-driven chatbots? Moderating roles of perceived innovativeness and active involvement

Acta Psychologica
In recent years, AI-driven chatbots have evolved into a transformative technological paradigm, deeply embedded in domains including retail, customer service, healthcare, and education.
Yanxinyue Liu, Kaige Zhang, Yan Zhang, Hua Pang, Bo Liu   +4 more
doaj   +1 more source

From Search Engines to Search Services: An End-User Driven Approach

, 2019
The World Wide Web is a vast and continuously changing source of information where searching is a frequent, and sometimes critical, user task. Searching is not always the user's primary goal but an ancillary task that is performed to find complementary information allowing to complete another task.
Bosetti, Gabriela, Firmenich, Sergio, Fernandez, Alejandro, Winckler, Marco, Rossi, Gustavo   +4 more
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

AI-MDD-UX: Revolutionizing E-Commerce User Experience with Generative AI and Model-Driven Development

Future Internet
E-commerce applications have emerged as key drivers of digital transformation, reshaping consumer behavior and driving demand for seamless online transactions.
Adel Alti, Abderrahim Lakehal
doaj   +1 more source

MutationDistiller: user-driven identification of pathogenic DNA variants

Nucleic Acids Res., 2019
MutationDistiller is a freely available online tool for user-driven analyses of Whole Exome Sequencing data. It offers a user-friendly interface aimed at clinicians and researchers, who are not necessarily bioinformaticians.
Daniela Hombach, M. Schuelke, E. Knierim, Nadja Ehmke, J. M. Schwarz, Björn Fischer-Zirnsak, D. Seelow   +6 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

A Philosophical Framework for Data-Driven Miscomputations

Philosophies
This paper introduces a first approach to miscomputations for data-driven systems. First, we establish an ontology for data-driven learning systems and categorize various computational errors based on the Levels of Abstraction ontology. Next, we consider
Alessandro G. Buda, Chiara Manganini, Giuseppe Primiero   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source