Results 131 to 140 of about 515,631 (298)

Bridging User-Centered Design and Requirements Engineering with GRL and Persona Cases [PDF]

, 2011
Despite the large body of i* research, there has been com- paratively little work on how goal-modelling techniques can help identify usability concerns. Recent work has considered how goal models might better integrate with User-Centered Design.
Faily, Shamal
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Harmonizing design and desire: Unveiling user-centered requirements for university buildings

Results in Engineering
The design of university buildings plays a critical role in users' productivity, health, and behavior. The design should incorporate end users' and architects' perceptions to prevent decreased satisfaction, productivity, and health issues.
Mohamed Yasser Arafat, Ahmed Atef Faggal, Laila Khodeir, Tamer Refaat   +3 more
doaj   +1 more source

Evaluation of the game development process of a location-based mobile game [PDF]

, 2014
There is a growing interest of government bodies and NGOs in using (serious) video games in awareness campaigns. Until now, however, little was known on how to set up such a campaign so as to effectively cater to the needs of different stakeholders ...
All, Anissa, Beg, Imran, Van Looy, Jan
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

UI/UX Design Planning of Ququ Bakery Application Using the User Centered Design (UCD) Method

Sistemasi: Jurnal Sistem Informasi
This study aims to design the user interface (UI) and user experience (UX) of a birthday cake ordering application for Ququ Bakery in Semarang, Central Java, using the User-Centered Design (UCD) approach.
Nabila Widya Anggraeni, Adi Nugroho
doaj   +1 more source

Modeling the early stages of a user-centered process in architectural design through adaptation of the methodologies of New Product Design [PDF]

, 2009
In order to reach a degree of quality in architectural buildings that is likely to lead to user satisfaction, architectural design relies on integrating user-related information even before generation of building concepts.
BOUCHARD, Carole, DUCHAMP, Robert, SONG, Heon   +2 more
core   +3 more sources