Results 171 to 180 of about 515,631 (298)

Evaluation of usability and acceptability of a Peruvian telemental health service for early assessment among vulnerable occupational workers: Mixed-method study with a user-centered design approach. [PDF]

PLoS One
Cainamarks-Alejandro JA, Cruz-Ausejo L, Burgos-Flores MA, Rosales-Rimache J, Astete-Cornejo J, Villarreal-Zegarra D.   +5 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

User-Centered Design

, 2017
Doroftei, Daniela, Cubber, Geert De, Wagemans, Rene, Matos, Anibal, Silva, Eduardo, Lobo, Victor, Cardoso, Guerreiro, Chintamani, Keshav, Govindaraj, Shashank, Gancet, Jeremi, Serrano, Daniel   +10 more
openaire   +3 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

User-centered design of a COPD care pathway for patients with cancer: a mixed-methods clinical trial protocol. [PDF]

Future Oncol
Lycan TW, Price SN, Mileham K, Stoen E, Ruiz J, Ohar JA, Norton D, Koch AL, Petty WJ, Birken SA.   +9 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

A Novel Primary Care Planning Informatics Tool Informed by Data-Driven Multimorbidity Grouping: User-Centered Design and Feasibility Testing. [PDF]

JMIR Form Res
Schuttner L, Daniels K, Venkatesh S, Hutchins F, Atchison K, Piegari R, Bober T, Zhao X, Rosland AM.   +8 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Patient Perceptions of Blockchain-Based Health Information Exchange: User-Centered Design Study.

J Med Internet Res
Guse R, Hu S, Thiebes S, Erler C, Caridia C, Stork W, Gersch M, Sunyaev A.   +7 more
europepmc   +1 more source

Patients' Expectations for App-Based Therapy in Knee Osteoarthritis: User-Centered Design Approach. [PDF]

JMIR Rehabil Assist Technol
Krištof Mirt P, Erjavec K, Krsnik S, Kotnik P, Mohsen H.   +4 more
europepmc   +1 more source