Results 201 to 210 of about 518,578 (347)

User-Centered Design

, 2017
Doroftei, Daniela, Cubber, Geert De, Wagemans, Rene, Matos, Anibal, Silva, Eduardo, Lobo, Victor, Cardoso, Guerreiro, Chintamani, Keshav, Govindaraj, Shashank, Gancet, Jeremi, Serrano, Daniel   +10 more
openaire   +3 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Stress and Well-Being Intervention and mHealth Delivery Adaptation for Latinx Millennial Caregivers: Qualitative User-Centered Design Approach. [PDF]

JMIR Nurs
Thomas Hebdon M, Dupree GD, Hernandez J, Cuevas H, Thomas M, Burt S, Peterson N, Horner SD.   +7 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Leveraging User-Centered Design and Usability and Skills Testing for a Novel Diabetes Survival Skills Toolkit. [PDF]

J Endocr Soc
Freeman S, Lecka L, Davis K, Prince G, Carthy K, Seley JJ, Song J, Lee J, Bailey SC, Khorzad R, Gatchell D, Ankenman B, Lewis DR, Holl JL, Wallia A.   +14 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Development of an HPV 16 rapid test founded in user-centered design with primary care clinicians.

Anal Methods
Brennan LP, Hamacher F, Claure LA, Claure Dips AL, Sembian S, Balian LN, Piepho AD, Ermel AC, Linnes JC, Rodriguez NM.   +9 more
europepmc   +1 more source

Developing a Quick Isolation Bed Inquiry System During the COVID-19 Outbreak: User-Centered Design Approach Based on the Toyota Production System. [PDF]

JMIR Form Res
Lin CC, Shen JH, Chang SL, Kuo TC, Huang HL, Lin CP, Huang HM.   +6 more
europepmc   +1 more source

Using the NIATx Model to Implement User-Centered Design of Technology for Older Adults [PDF]

, 2016
David H. Gustafson, Adam Maus, Julianne Judkins, Susan Dinauer, Andrew Isham, Roberta Ann Johnson, Gina Landucci, Amy K. Atwood   +7 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source