Results 71 to 80 of about 37,804 (303)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Road taxes, road user charges and earmarking [PDF]
The UK Road Fund was set up in 1921 and financed by earmarked taxes, but was unsuccessful as a form of road finance and abandoned in 1937. The paper examines why earmarking failed and what problems arise for replacing road taxes by hypothecated road ...
Georgina Santos, David M. Newbery
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Harmonization of aviation user charges in the North Atlantic airspace [PDF]
, 2008 Thesis (S.M. in Transportation)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering; and, (S.M.)--Massachusetts Institute of Technology, Sloan School of Management, Operations Research Center, 2008.Includes ...
Gaudet, Megan Brett
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
User charges and their impact on planned and unplanned hospital use: evidence from Portugal [PDF]
, 2021 Predicted values for individual’s expected costs related to emergency department visits and primary care unit (PCU) appointments are constructed using Portuguese survey data.
Jesus, Augusto Varela Rodrigues Gonçalves de
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Expanding education through user charges : what can be achieved in Malawi and other LDCs ? [PDF]
, 1986 International audienceTwo features mark the education sector in many LDCs today: first, education is publicly provided; and second. governments are faced with severe financial constraints. As a result, enrollmrnts are confined to low Ievels, and there is
Tan, Jee-Peng, Mingat, Alain
core +1 more source
Bulletin of the World Health OrganizationOBJECTIVE: To assess the effects of user charges on the uptake of health services in low- and middle-income countries. METHODS: A systematic search of 25 social science, economics and health literature databases and other sources was performed to ...
Mylene Lagarde, Natasha Palmer
doaj +1 more source
Neue Wege der Verkehrswegefinanzierung im Spiegel raumordnerischer Ziele und Grundsätze
Raumforschung und Raumordnung, 2003 The first privately operated motorway projects and heavy truck toll collection schemes on German motorways are components of an intensified integration of road usage and financing.
Claus -Friedrich Laaser +1 more
doaj +1 more source