Results 81 to 90 of about 37,804 (303)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Mileage-Based Road User Charges [PDF]
, 2016 This report examines mileage-based user charges as an possible source of highway funding. Federal highway and public transportation programs are funded mainly by taxes on motor fuel that flow into the Highway Trust Fund (HTF). The tax rates, set on a per-
Kirk, Robert S., Levinson, Marc
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Calculating External Costs of Transportation in Norway
European Journal of Transport and Infrastructure Research, 2000 Transport activities are known to have substantial negative external effects. One of the reasons for trying to value these effects is that the cost to society of using a specific transport mode should be reflected in the price that is paid by the ...
Knut S. Eriksen
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
The impact of user charges on patient choice of healthcare services in Ireland [PDF]
, 2016 This research assesses the impact of user charges in the context of consumer choice to ascertain how user charges in healthcare impact on patient behaviour in Ireland.
Fox, Aimée
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Integrated generation of vortices and frequency conversion with metasurfaces
Light: Science & ApplicationsThe generation of optical vortices in compact systems and across different spectral regions can open new horizons for their applications in end-user devices.
Jinyong Ma +2 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Economic and Welfare Effects of the Abolition of Health User Fees : Evidence from Uganda [PDF]
The authors use household level data for Uganda for 1999-2000 and 2002-03, before and after the abolition of user fees for public health services, to explore the effect of this policy on different groups'ability to access health services and morbidity ...
Deininger, Klaus, Mpuga, Paul
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Exploring the Effects of User Fees, Quality of Care and Utilization of Health Services on Enrolment in Community Health Fund, Bagamoyo District, Tanzania. [PDF]
, 2012 The co-existence of Community Health Fund (CHF) and user fees in Tanzania as health financial mechanisms have affected to CHF enrolment. However, little is known about the effect of user fees on CHF enrolment, non-enrollment and drop-out. The study aimed
Lekashingo, Lawrence Davidson +1 more
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