Results 101 to 110 of about 5,792,312 (249)

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

User-experience Ecosystems: A Tool for Understanding User Experiences From the User's Viewpoint

open access: yes, 2011
User experience has been established as a valid concept when the user’s viewpoint of interactive products and services is considered. However, the definitions of user experience are currently linked only to the designed product or service. From the user’s perspective, the usage of a product usually includes the use of other resources as well, and all ...
openaire   +4 more sources

Deceptive Patterns: UX and Web Designers’ Perspectives

open access: yes
Over recent years, digital platforms and services have become ever more competitive. As competition has intensified, companies have found new ways to maximize profit.
Ahola, Markus   +4 more
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

A Study of User Experience: Aesthetic, Tangible User Interface Concepts in the Context of Adaptive Hotel Room [PDF]

open access: yes, 2015
Nopeasti kehittyvä teknologia ja digitalisoituminen vaikuttavat yhä voimakkaammin elämäämme. Eri laitteiden avulla pyrimme pysymään yhteydessä fyysisen maailman rinnalle syntyneeseen digitaaliseen todellisuuteen.
Pekkanen, Siina
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Compromise solutions for water and energy sustainability: a VIKOR multi-criteria assessment

open access: yesApplied Water Science
Integrating sustainability into water and energy systems requires decision-making frameworks capable of addressing multiple and often conflicting objectives.
Minghui Wei   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

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