Results 101 to 110 of about 5,908,797 (296)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Frontiers in Computer ScienceIntroductionMental health crisis response requires police officers to regulate their emotional and physiological states while making rapid decisions in socially complex situations.
John E. Muñoz +3 more
doaj +1 more source
Launching a Native App: Lessons Learned in Academic Libraries
Weave: Journal of Library User Experience, 2014 If your library has a website and your users have mobile devices, congratulations: you have a mobile user experience. But is that experience a good one for your users? Libraries seeking to offer good user experience on mobile devices have two choices:
Samantha Raddatz
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
User-experience Ecosystems: A Tool for Understanding User Experiences From the User's Viewpoint
, 2011 User experience has been established as a valid concept when the user’s viewpoint of interactive products and services is considered. However, the definitions of user experience are currently linked only to the designed product or service. From the user’s perspective, the usage of a product usually includes the use of other resources as well, and all ...
openaire +4 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Deceptive Patterns: UX and Web Designers’ Perspectives
Over recent years, digital platforms and services have become ever more competitive. As competition has intensified, companies have found new ways to maximize profit.
Ahola, Markus +4 more
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