Results 81 to 90 of about 444,077 (311)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Enhancing Going Concern Prediction With Anchor Explainable AI and Attention-Weighted XGBoost

IEEE Access
In the rapidly evolving sector of financial analytics, predicting a firm’s going concern status accurately is vital for informed user decisions. This study introduces a novel method that synergizes Anchor Explainable Artificial Intelligence (XAI ...
Putthiporn Thanathamathee, Siriporn Sawangarreerak, Dinna Nina Mohd Nizam   +2 more
doaj   +1 more source

A Framework for Improving User Experience in Ambient Assisted Living [PDF]

Ambient Assisted Living (AAL) refers to the integration of all kind of computerized devices into a home environment in order to provide their residents with a better quality of life.
Robinet, Alexia, Picking, Rich, Grout, Vic   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Launching a Native App: Lessons Learned in Academic Libraries

Weave: Journal of Library User Experience, 2014
If your library has a website and your users have mobile devices, congratulations: you have a mobile user experience. But is that experience a good one for your users? Libraries seeking to offer good user experience on mobile devices have two choices:
Samantha Raddatz
doaj   +1 more source

A Study of User Experience: Aesthetic, Tangible User Interface Concepts in the Context of Adaptive Hotel Room

, 2015
Nopeasti kehittyvä teknologia ja digitalisoituminen vaikuttavat yhä voimakkaammin elämäämme. Eri laitteiden avulla pyrimme pysymään yhteydessä fyysisen maailman rinnalle syntyneeseen digitaaliseen todellisuuteen.
Pekkanen, Siina
core  

Re-think user experience

, 2021
LAUREA MAGISTRALEre_think user experience è il nostro progetto di tesi che argomenta tematiche riguardanti la sostenibilità ambientale. La ricerca degli argomenti è focalizzata sul rapporto tra l’utenza e lo spazio che la prima abita quotidianamente.
Di Pilato, Sergio Francesco, Chiapponi, Simone   +1 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source