Results 211 to 220 of about 2,245,729 (347)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Bridging the Gap in Genomic Implementation: Identifying User Needs for Precision Nephrology. [PDF]

Kidney Int Rep
Kneifati-Hayek JZ, Zachariah T, Ahn W, Khan A, Kiryluk K, Mohan S, Weng C, Gharavi AG, Nestor JG.   +8 more
europepmc   +1 more source

Designing a mHealth clinical decision support system for Parkinson's disease: a theoretically grounded user needs approach. [PDF]

BMC Med Inform Decis Mak, 2020
Timotijevic L, Hodgkins CE, Banks A, Rusconi P, Egan B, Peacock M, Seiss E, Touray MML, Gage H, Pellicano C, Spalletta G, Assogna F, Giglio M, Marcante A, Gentile G, Cikajlo I, Gatsios D, Konitsiotis S, Fotiadis D.   +18 more
europepmc   +1 more source

Contextual queries and situated information needs for mobile users

, 2010
Annika Hinze, Carole Chang, David M. Nichols   +2 more
openalex   +1 more source

User Needs in Drug Delivery: Unique Challenges with Combination Products [PDF]

J. Anthony Towns, Andrew Susott, Muriel Didier   +2 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Adjusting the 15-method to Danish general practice: identification of barriers, facilitators, and user needs. [PDF]

BMC Prim Care
Schøler PN, Søndergaard J, Rasmussen S, Nielsen AS.   +3 more
europepmc   +1 more source

A model for system users to develop a software needs specification and to evaluate the ability of systems to comply with the specification

, 2001
Saier, Kevin Patrick
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Maternal health applications: Qualitative findings of user needs. [PDF]

Digit Health
Babu S, Park N, Woodland G, Garcia N, Page W, Page R.   +5 more
europepmc   +1 more source