Results 31 to 40 of about 118,119 (154)

High grade sarcoma with chondrosarcomatous differentiation in primary uterine leiomyosarcoma; A rare case and review of literature

Gynecologic Oncology Reports, 2022
Primary uterine leiomyosarcoma (LMS) with chondrosarcomatous differentiation is extremely rare. We report a case of a 68-year-old, African American woman who presented with postmenopausal bleeding. Ultrasonography (USG) revealed multiple uterine fibroids.
Qandeel Sadiq, Farhan Khan
doaj   +1 more source

A novel germline mutation in hMLH1 in three Korean women with endometrial cancer in a family of Lynch syndrome: case report and literature review

Hereditary Cancer in Clinical Practice, 2021
Background Endometrial cancer is often the sentinel cancer in women with Lynch syndrome, among which endometrioid endometrial cancer is the most common. We found a Korean case of uterine carcinosarcoma associated with Lynch syndrome.
Youn-Joon Jung, Hye Ryoun Kim, Mi Kyung Kim, Eun-Ju Lee   +3 more
doaj   +1 more source

Outcomes of carcinosarcoma in a tertiary care institution in India

South Asian Journal of Cancer, 2018
Background: Carcinosarcoma is a rare malignancy, and reports are often mixed along with other sarcomas. The literature on uterine carcinosarcoma per se is sparse. Aims: This study aims to evaluate the demography, survival, and optimal treatment strategy
Anne George Cherian, Anitha Thomas, Ajit Sebastian, Tunny Sebastian, Vinotha Thomas, Rachel G Chandy, Abraham Peedicayil   +6 more
doaj   +1 more source

Metastatic Uterine Carcinosarcoma to the Orbit

, 2021
Metastases of solid tumors to the eye and ocular adnexa are rare. Herein, the authors describe the clinical, histologic, and immunohistochemical findings of a patient with a history of adenocarcinoma of the colon and a uterine carcinosarcoma (malignant ...
Sander R. Dubovy, Patel, Nish, Nimesh A. Patel, David T. Tse, Sana Qureshi, Tse, David T., Ghassibi, Mark P., Qureshi, Sana, Nish Patel, Mark P. Ghassibi, Patel, Nimesh A., Dubovy, Sander R.   +11 more
core   +1 more source

Preferential human epidermal growth factor receptor 2 expression in myometrial and lymphovascular invasion of a uterine carcinosarcoma: A case report

SAGE Open Medical Case Reports, 2022
This case report describes a unique pattern of human epidermal growth factor receptor 2 expression in a patient with uterine carcinosarcoma. The endometrial tumor showed biphasic morphology composed of serous carcinoma and a heterologous high-grade ...
Joseph Gillam, Raghavendra Pillappa, Michael Idowu, Cecelia Boardman, Stephanie A Sullivan, Sadia Sayeed   +5 more
doaj   +1 more source

A synchronous diagnosis of uterine carcinosarcoma and serous tubal carcinoma. A case report and literature review

, 2022
20.500.12530/87887We report a rare case of uterine carcinosarcoma involving a 74-year-old woman. The patient complained of posmenopausal bleeding. The disease was eventually diagnosed as simultaneous uterine carcinosarcoma and high-grade serous tubal ...
Morillo, V. P. Quintero, Goni, A. Zapico, Corral, M. C. Diez, Sanchez, S. Alvarez, Garcia, J. M. Barreiro, Gonzalez, A. Couso, Ruiz, P. L. Valenzuela   +6 more
core   +1 more source

Cervical Carcinosarcoma: Current Understanding on Pathogenesis, Diagnosis, Management and Future Perspectives

Clinical Medicine Insights: Oncology, 2021
Cervical carcinosarcoma (CCS) is a rare aggressive tumor which was referred to as a sarcoma initially with its morbidity less than 1% of all cervical cancers. Four theories have been proposed for the pathogenesis of CCS.
Xinyao Shu, Yuwen Zhou, Guixia Wei, Xiaorong Chen, Meng Qiu   +4 more
doaj   +1 more source

Uterine carcinosarcoma: a rare and aggressive neoplasm [PDF]

Uterine carcinosarcoma (UCS) is a rare highly aggressive tumor accounting for 2-3% of all uterine malignancies. It’s characterized by postmenopausal bleeding and often presents with a palpable pelvic mass.
Agrawal, Trupti, Satia, Meena, Bandhu, Rishita, Badhwar, Vijaya   +3 more
core   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Cancer antigen 125 is associated with disease status in uterine carcinosarcoma

Rare Tumors, 2019
Uterine carcinosarcoma is a rare and aggressive tumor with poor outcomes. Cancer antigen 125 is routinely used to track the disease course of ovarian cancer and has been suggested as a biomarker in other aggressive forms of uterine cancer.
Malcolm Strachan Ross, Chelsea Kilpatrick Chandler, Koji Matsuo, John Austin Vargo, Esther Elishaev, Nalyn Siripong, Jessica Layne Berger, Joseph Leo Kelley, Sarah Elizabeth Taylor   +8 more
doaj   +1 more source