Results 51 to 60 of about 2,393,029 (295)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A potential diagnostic biomarker: Proteasome LMP2/b1i-differential expression in human uterus neoplasm [PDF]

, 2012
Uterine leiomyosarcoma (ULMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine ULMS
Nobuo Yaegashi, Akiko Horiuchi, Takuma Hayashi, Hiroyuki Aburatani, Susumu Tonegawa, Ikuo Konishi   +5 more
core  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Епідеміологічні особливості поєднаних гіперпроліферативних процесів жіночої репродуктивної системи

Medičnì Perspektivi, 2013
The study involved 622 women of reproductive age with such hyperproliferative processes of the pelvic organs as uterine leiomyoma, endometrial hyperplasia and endometriosis. We studied main epidemiological factors inherent in these diseases.
V. H. Halytska, I. V. Ivach, Yu. V. Donska, V. O. Potapov, M. V. Medvedyev   +4 more
doaj   +1 more source

Morphological changes in bitches endometrium affected by cystic endometrial hyperplasia - pyometra complex – the value of histopathological examination

BMC Veterinary Research, 2021
Background Cystic endometrial hyperplasia-pyometra complex (CEH-P) is one of the most common uteropathies in bitches. In diseases with mild or obscure clinical signs and normal uterine size, a diagnosis based on a clinical assessment might be incorrect ...
Magdalena Woźna-Wysocka, Marta Rybska, Beata Błaszak, Bartłomiej M. Jaśkowski, Magdalena Kulus, Jędrzej M. Jaśkowski   +5 more
doaj   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Ethno-Racial Differences in Age and Symptom Severity Among Pre-Menopausal Women Commencing Treatment for Benign Gynecological Conditions with a Levonorgestrel-Releasing Intrauterine Device

Health Equity
Introduction: Levonorgestrel-releasing intrauterine devices (LNG-IUDs) can be effective treatments for benign gynecological conditions, but there may be ethno-racial differences in how patients receive treatment.
Michael J. Green, Kemi M. Doll, Mollie E. Wood, Annie G. Howard, Lauren G. Anderson, Joacy G. Mathias, Natalie A. Rivadeneira, Erin T. Carey, Timothy S. Carey, Wanda Nicholson, Til Stürmer, Evan R. Myers, Whitney R. Robinson   +12 more
doaj   +1 more source

Uterine fibroids increase the risk of thyroid goiter and thyroid nodules

Scientific Reports, 2022
Uterine fibroid and benign thyroid disease are both common diseases in women. This study aimed to evaluate whether these diseases are related. We established the uterine fibroid group according to diagnosis and surgery codes using the Korea National ...
Jin-Sung Yuk, Jung Min Kim
doaj   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Differences in reproductive and productive performance and removal from the herd associated with time to clinical cure in dairy cows treated for metritis

Journal of Dairy Science
: The objectives of this study were to assess differences in lactational performance (reproduction, milk production, and removal from the herd) associated with time to clinical cure of metritis.
F.N.S. Pereira, E.B. de Oliveira, V.R. Merenda, F.S. Lima, R.C. Chebel, K.N. Galvão, J.E.P. Santos, R.S. Bisinotto, C.C. Figueiredo   +8 more
doaj   +1 more source