Results 91 to 100 of about 243,398 (291)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

It's Harder to Push, When I Have to Push Hard—Physical Exertion and Fatigue Changes Reasoning and Decision-Making on Hypothetical Moral Dilemmas in Males

Frontiers in Behavioral Neuroscience, 2018
Despite the prevalence of physical exertion and fatigue during military, firefighting and disaster medicine operations, sports or even daily life, their acute effects on moral reasoning and moral decision-making have never been systematically ...
Matthias Weippert, Michel Rickler, Steffen Kluck, Kristin Behrens, Manuela Bastian, Anett Mau-Moeller, Sven Bruhn, Alexander Lischke   +7 more
doaj   +1 more source

Utilitarian Welfare and Representation Guarantees of Approval-Based Multiwinner Rules

, 2020
To choose a suitable multiwinner voting rule is a hard and ambiguous task. Depending on the context, it varies widely what constitutes the choice of an ``optimal'' subset of alternatives.
Lackner, Martin, Skowron, Piotr
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Utilitarianism or Welfarism: Does it Make a Difference? [PDF]

We show that it is possible to reconcile the utilitarian and welfarist principles under the\r\nrequirement of unanimity provided that the set of profiles over which the consensus is\r\nattained is rich enough.
Nicolas GRAVEL (AMSE (GREQAM) et Aix-Marseille University), Patrick MOYES ( GREThA, CNRS, UMRS 5113)   +1 more
core   +3 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Utilitarianism

, 2002
Surveying the historical development and the present condition of utilitarian ethics, Geoffrey Scarre examines the major philosophers from Lao Tzu in the fifth century BC to Richard Hare in the twentieth. Utilitarianism traces the 'doctrine of utility' from the moralists of the ancient world, through the Enlightenment and Victorian utilitarianism up to
openaire   +3 more sources