Results 131 to 140 of about 188,183 (294)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Sacred Vows, Public Purposes: Religion, the Marriage Movement and Marriage Policy [PDF]
, 2002 Focuses on the ways in which public policy is promoting marriage, church-state cooperation on behalf of marriage, and the likelihood that these public policies will meet with success.
W. Bradford Wilcox
core
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
, 2018 A heterogeneous resource, such as a land-estate, is already divided among several agents in an unfair way. It should be re-divided among the agents in a way that balances fairness with ownership rights.
Segal-Halevi, Erel
core
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kinh tế và Quản trị kinh doanhThis study examines the impact of interaction quality on the continuous usage intention to use Live-Streaming commerce (LS) through perceived values.
Nguyễn Hữu Khôi
doaj +1 more source
PENGARUH UTILITARIAN VALUE DAN HEDONIC VALUE TERHADAP KEPUASAN KONSUMEN TOSERBA
Jurnal Ekonologi Ilmu Manajemen, 2016 Penelitian ini difokuskan pada Pengaruh Utilitarian Value Dan Hedonic Value Terhadap Kepuasan Konsumen di Toserba Pajajaran Ciamis. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan metode survey. Berdasarkan hasil penelitian dapat ditarik kesimpulan sebagai berikut : 1) Terdapat pengaruh antara utilitarian value terhadap kepuasan ...
openaire +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source