Results 41 to 50 of about 57,497 (243)

The effect of anti-TNF α therapy on refractory non-infectious pediatric uveitis in Saudi Arabia

BMC Ophthalmology
Purpose To report the outcomes of anti-tumor necrosis factor alpha (anti-TNF-α) treatment in children with refractory non-infectious uveitis. Methods Retrospective chart review for all children aged ≤ 18 years, diagnosed to have non-infectious uveitis ...
Abeer Aljahdali, Abrar A. Alhawsawi, Maram Alenazi, Moustafa S. Magliyah, Hassan Al-Dhibi   +4 more
doaj   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Severe acute multi-systemic failure with bilateral ocular toxoplasmosis in immunocompetent patients from urban settings in Colombia: Case reports

American Journal of Ophthalmology Case Reports, 2020
Propose: To report two cases of severe acute multi-systemic failure with bilateral ocular toxoplasmosis in immunocompetent patients from urban settings in Colombia.
Diana Alejandra Cortés, María Camila Aguilar, Hernán Andres Ríos, Francisco José Rodríguez, Kelly Verónica Montes, Jorge Enrique Gómez- Marín, Alejandra de-la-Torre   +6 more
doaj   +1 more source

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Pattern of uveitis in a tertiary eye care hospital in hilly area of North India

TNOA Journal of Ophthalmic Science and Research, 2023
Aim: Pattern of uveitis in a tertiary eye care centre in Hilly area of North India. Materials and Methods: All new cases of uveitis seen in Out Patient Department (OPD) and In Patient Department (IPD) of department of Ophthalmology from June 2017 to May ...
Sushil Ojha, Reena Sharma, Nitin K Jain, Vaibhav K Jain   +3 more
doaj   +1 more source

Pediatric Uveitis

Asia-Pacific Journal of Ophthalmology, 2018
Pediatric uveitis differs from adult-onset uveitis and is a topic of special interest because of its diagnostic and therapeutic challenges. Children with uveitis are often asymptomatic and the uveitis is often chronic, persistent, recurrent, and resistant to conventional treatment.
Nicole Shu-Wen, Chan, Jessy, Choi, Chui Ming Gemmy, Cheung   +2 more
openaire   +2 more sources

Tissue Damage in Rheumatoid Arthritis Is Genetically Linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts

Arthritis &Rheumatology, EarlyView.
Objective Both susceptibility to, and severity of, rheumatoid arthritis (RA) is associated with the rs26232 C allele. Our primary aim was to identify the biologic mechanism underlying this association. Methods Expression of surrounding genes was compared among rs26232 genotypes.
Kevin J. Sheridan, Emma R. Dorris, Maria Inês Pimenta, Jemma Falkov, Matthew Fisher, Sam Pledger, Hector Devey, Munitta Muthana, Denis C. Shields, Richard E. Mains, Betty A. Eipper, Christopher D. Buckley, Anthony G. Wilson   +12 more
wiley   +1 more source

Real-Life Data on the Efficacy of Canakinumab in Patients with Adult-Onset Still’s Disease

Mediators of Inflammation, 2020
Background. Interleukin-1 inhibition has revealed to be a successful treatment approach for patients with adult-onset Still’s disease (AOSD). However, real-life experience is focused on the use of anakinra, while data about canakinumab (CAN) are mainly ...
Antonio Vitale, Virginia Berlengiero, Jurgen Sota, Luisa Ciarcia, Nicola Ricco, Sara Barneschi, Mariam Mourabi, Giuseppe Lopalco, Chiara Marzo, Francesca Bellisai, Florenzo Iannone, Bruno Frediani, Luca Cantarini   +12 more
doaj   +1 more source

High‐Resolution Deep Learning Dixon Magnetic Resonance Imaging of the Sacroiliac Joints Is Noninferior to Standard Magnetic Resonance Imaging in Patients With Suspected Axial Spondyloarthritis

Arthritis &Rheumatology, EarlyView.
Objective To compare the multisequence standard magnetic resonance imaging (sMRI) protocol of the sacroiliac joints with a single high‐resolution deep learning–reconstructed Dixon sequence (DL‐Dixon) in patients with suspected axial spondyloarthritis (axSpA). Methods Seventy‐six patients with chronic low back pain and suspected axSpA underwent clinical,
Dominik Deppe, Mariam Koka, Fabian Proft, Sevtap Tugce Ulas, Kay‐Geert Hermann, Denis Poddubnyy, Mikhail Protopopov, Henriette Baum, Hildrun Haibel, Mehrgan Shahryari, Valeria Rios Rodriguez, Jens Vogel‐Claussen, Torsten Diekhoff   +12 more
wiley   +1 more source

Bilateral acute necrotizing retinitis due to cytomegalovirus infection in an infant: Challenging case report

American Journal of Ophthalmology Case Reports, 2019
Purpose: To report a case of bilateral acute necrotising retinitis due to cytomegalovirus infection (CMV) in an Asian Indian infant. Observations: An Asian Indian infant born with a birth weight of 1000 g at 26 week of gestation acquired cytomegalovirus ...
Padmamalini Mahendradas, Shivani Sinha, Anand Vinekar, Maralusiddappa Pradeep, Bhujang K. Shetty   +4 more
doaj   +1 more source