Results 51 to 60 of about 60,445 (238)

Delayed-onset cytomegalovirus retinitis after 0.2 µg/day fluocinolone acetonide implantation: a case series

Journal of Ophthalmic Inflammation and Infection
Purpose To describe the clinical features and outcomes of cytomegalovirus retinitis (CMVR) presenting after intravitreal fluocinolone acetonide (FAc) implantation.
Anamika Patel, Ilaria Testi, Carlos Pavesio   +2 more
doaj   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

The Clinical Spectrum and Outcomes of Ocular Syphilis in Saudi Arabia: The Emergence of a Uveitic Masquerader

Journal of Epidemiology and Global Health
This retrospective multicenter cohort study aimed to describe the clinical features and report the outcomes of the management of ocular syphilis in Saudi Arabia.
Abrar A. Alhawsawi, Abeer Aljahdali, Enas Magharbil, Asma Alzuabi, Abdulrahman F. Albloushi, Dhoha Alhamad, Abrar K. Alsalamah, Sulaiman M. Alsulaiman, Fatimah Al Hammad, Moustafa S. Magliyah, Hassan A. Al-Dhibi   +10 more
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Acral Lentiginous Melanoma With NRAS Mutation and Ocular Surface Toxicity Following Immunotherapy and Investigational KRASG12C Inhibitor: Case Report

Case Reports in Oncological Medicine
We report the case of a patient with metastatic foot melanoma enrolled in a clinical trial of the anti-RAS agent RMC-6236 who developed chronic bilateral corneal epithelial defects and thinning, likely secondary to the systemic effects of targeted ...
Elisah Huynh, Andrew Gregory, Peter Y. Chang   +2 more
doaj   +1 more source

Optical coherence tomography angiography (OCTA) of retinal vasculature in patients with post fever retinitis: a qualitative and quantitative analysis

Scientific Reports, 2021
Post fever retinitis is a heterogenous entity that is seen 2–4 weeks after a systemic febrile illness in an immunocompetent individual. It may occur following bacterial, viruses, or protozoal infection. Optical coherence angiography (OCTA) is a newer non-
Srinivasan Sanjay, Santosh Gopi Krishna Gadde, Sameeksha Agrawal, Padmamalini Mahendradas, Nivedhitha Govindaswamy, Ankush Kawali, Chaitra Jayadev, Sajjan Sangai, Abhijit Sinha Roy, Rohit Shetty   +9 more
doaj   +1 more source

Oral Antioxidant Provides Adjunctive Therapeutic Benefits Alongside Dexamethasone in a Rat Model of Endotoxin-Induced Uveitis. [PDF]

Vet Med Sci
In a rat model of endotoxin‐induced uveitis, oral antioxidant supplementation combined with dexamethasone significantly reduced TNF‐α, increased IL‐10, and produced the highest superoxide dismutase activity versus dexamethasone alone, supporting its potential as an adjunctive strategy to mitigate oxidative stress and inflammation.
Yang SJ, Kim JY.
europepmc   +2 more sources

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

The effect of anti-TNF α therapy on refractory non-infectious pediatric uveitis in Saudi Arabia

BMC Ophthalmology
Purpose To report the outcomes of anti-tumor necrosis factor alpha (anti-TNF-α) treatment in children with refractory non-infectious uveitis. Methods Retrospective chart review for all children aged ≤ 18 years, diagnosed to have non-infectious uveitis ...
Abeer Aljahdali, Abrar A. Alhawsawi, Maram Alenazi, Moustafa S. Magliyah, Hassan Al-Dhibi   +4 more
doaj   +1 more source

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

Advanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han, Jiaqi Ding, Zonghao Pan, Weitai He, Xue Kang, Cong Zhao, Yi Li, Di Wu, Hongzeng Li, Kaixi Ren, Jiaji Lin, Jun Guo   +11 more
wiley   +1 more source