Results 71 to 80 of about 1,983,859 (250)
Treatment of HBV HCV Co-Infection: Exceeded Response [PDF]
, 2011 Os vírus da hepatite B (VHB) e da hepatite C (VHC) constituem a causa mais frequente de doença hepática crónica. A partilha de vias de transmissão contribui para o risco de coinfecção VHB-VHC.
Barbosa, J, Calinas, F
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
A Brazilian glycoprotein E-negative bovine herpesvirus type 1.2a (BHV-1.2a) mutant is attenuated for cattle and induces protection against wild-type virus challenge [PDF]
The authors previously reported the construction of a glycoprotein E-deleted (gE-) mutant of bovine herpesvirus type 1.2a (BHV-1.2a). This mutant, 265gE-, was designed as a vaccinal strain for differential vaccines, allowing the distinction between ...
Esteves, P.A. +7 more
core +1 more source
O hábito alimentar dos morcegos (Mammalia, Chiroptera) e sua relação com a diversidade viral [PDF]
, 2016 Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Biológicas, Programa de Pós-Graduação em Zoologia, 2016.Os morcegos são reconhecidos como hospedeiros de uma grande variedade de vírus.
Teixeira, Paula Galvão
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
EntomoBrasilis, 2017 . This study describes ecological data obtained in a rural area in the State of Mato Grosso, including the insects belonging to the family Culicidae, especially those framed as potential vectors of tropical diseases.
Fábio Alexandre Leal-Santos +10 more
doaj +1 more source
Recent sylvatic yellow fever virus transmission in Brazil: the news from an old disease
Virology Journal, 2020 Yellow fever (YF) is an acute viral disease, affecting humans and non-human primates (NHP), caused by the yellow fever virus (YFV). Despite the existence of a safe vaccine, YF continues to cause morbidity and mortality in thousands of people in Africa ...
Natalia Ingrid Oliveira Silva +6 more
doaj +1 more source
Viral modulation of interferon (IFN) responses to african swine fever virus (ASFV) [PDF]
, 2011 Tese de mestrado. Biologia (Biologia Humana e Ambiente). Universidade de Lisboa, Faculdade de Ciências, 2011A imunidade inata constitui a primeira resposta dada por um hospedeiro quando atacado por agentes patogénicos. A resposta imune baseia-se em genes
Costa, Emanuel Nery de Oliveira Quartin, 1986-
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Seleção assistida com uso de marcador molecular para resistência a potyvírus em pimentão
Pesquisa Agropecuária Brasileira, 2012 O objetivo deste trabalho foi determinar a presença do alelo Pvr4, que confere resistência contra o PepYMV (Pepper yellow mosaic virus), em genótipos de pimentão comunmente encontrados no mercado brasileiro, com uso de um marcador molecular codominante ...
Douglas Willian Nogueira +5 more
doaj +1 more source