Results 81 to 90 of about 2,019,555 (251)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Species composition and fauna distribution of mosquitoes (Diptera: Culicidae) and its importance for vector-borne diseases in a rural area of Central Western - Mato Grosso, Brazil

EntomoBrasilis, 2017
. This study describes ecological data obtained in a rural area in the State of Mato Grosso, including the insects belonging to the family Culicidae, especially those framed as potential vectors of tropical diseases.
Fábio Alexandre Leal-Santos, Adaiane Catarina Marcondes Jacobina, Maria Madalena de Oliveira, Marinalva Brasilina Arruda Santana, Otacília Pereira Serra, Aldimara Vaillant Gonçalves, Angela Regina Serafine Garcêz, Sirlei Franck Thies, Renata Dezengrine Slhessarenko, Elisangela Santana de Oliveira Dantas, Diniz Pereira Leite-Jr   +10 more
doaj   +1 more source

Treatment of HBV HCV Co-Infection: Exceeded Response [PDF]

, 2011
Os vírus da hepatite B (VHB) e da hepatite C (VHC) constituem a causa mais frequente de doença hepática crónica. A partilha de vias de transmissão contribui para o risco de coinfecção VHB-VHC.
Barbosa, J, Calinas, F
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Seleção assistida com uso de marcador molecular para resistência a potyvírus em pimentão

Pesquisa Agropecuária Brasileira, 2012
O objetivo deste trabalho foi determinar a presença do alelo Pvr4, que confere resistência contra o PepYMV (Pepper yellow mosaic virus), em genótipos de pimentão comunmente encontrados no mercado brasileiro, com uso de um marcador molecular codominante ...
Douglas Willian Nogueira, Danilo Gustavo Nogueira, Wilson Roberto Maluf, Gabriel Mascarenhas Maciel, Antônia dos Reis Figueira, Cícero Beserra de Menezes   +5 more
doaj   +1 more source

Caraterização virológica dos vírus da gripe que circularam em Portugal na época 2014/2015 [PDF]

, 2015
Introdução e objetivo: A monitorização contínua das propriedades antigénicas e genéticas dos vírus da gripe é essencial, quer para a seleção anual das estirpes virais a incluir na vacina, quer para identificar novas linhas de orientação da terapêutica ...
Barreiro, Paula, Costa, Inês, Cristóvão, Paula, Duarte, Sílvia, Guiomar, Raquel, Machado, Ausenda, Nunes, Baltazar, Pechirra, Pedro, Rodrigues, Ana Paula, Roque, Carla   +9 more
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Human case of West Nile neuroinvasive disease in Portugal, summer 2015 [PDF]

, 2015
A case of West Nile virus (WNV) infection was reported in the Algarve region, Portugal, in the first week of September 2015. WNV is known to circulate in Portugal, with occasional reports in horses and birds (2004 to 2011) and very sporadically human ...
Alves, M. J., Fevereiro, M., Gomes, S., Luz, T., Osório, H. C., Parreira, P., Proença, P., Zé-Zé, L.   +7 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Presença do vírus da síndrome da mancha branca em crustáceos decápodes silvestres em lagoas costeiras no Sul do Brasil

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2012
A presença do vírus da síndrome da mancha branca (em inglês WSSV) nas principais espécies de camarões, siris e caranguejos de cinco lagoas que recebem o efluente de fazendas afetadas pela enfermidade foi detectada por nested PCR, e inclusões virais nos ...
S.W. Costa, A.P.M. Fraga, A.S. Zamparetti, M.R.F. Marques, E.R. Andreatta   +4 more
doaj   +1 more source

Növényi víruskórókozók szisztemikus mozgásának vizsgálata korszerű védekezési stratégia kialakításához = Investigation of the systemic movement of cucumoviruses in order to develop new defence strategies [PDF]

, 2013
A cucumovírus nemzetségbe tartozó uborka mozaik vírus az egyik legszélesebb gazdanövénykörrel rendelkező növényi vírusoknak. Genomja három RNS-en elosztva, összesen öt fehérjét kódol.
Kiss, László, Salánki, Katalin, Tisza, Viktória   +2 more
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