Results 101 to 110 of about 1,989,476 (247)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Produção de um anticorpo policlonal contra a proteína viral [PDF]
, 2013 TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Agrárias. Curso de Engenharia de Aquicultura.A carcinicultura mundial vem enfrentando sérios problemas de ordem sanitária, especialmente de origem viral, sendo a principal ...
Bona, Ananice
core
Clinical and Biomedical Research, 2019 Introdução: A utilização da terapia com antirretroviral (TARV) é um dos maiores desafios para o sucesso do tratamento para HIV/AIDS, uma vez que é uma das ferramentas contra a pandemia, possibilitando a melhoria da qualidade de vida e longevidade da ...
Bruna Fernandes Brunetta +3 more
doaj
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2003 The aim of this paper is to report the occurrence of apoptosis in peripheral blood leukocytes and in syncytia induced by experimental infection of dogs with canine distemper virus.
Moro L. +5 more
doaj
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Apresentação - Um vírus mais maligno [PDF]
O ano de 2021 começou a trazer, sempre pela ciência, uma esperançapara amenizar os efeitos desastrosos que a pandemia da Covid19 causouno mundo. Esse vírus teimoso começa a ser abatido com a chegada e asaplicações da vacina contra ele.
Chiachiri, Roberto
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