Results 91 to 100 of about 2,019,555 (251)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Morphometric analysis of the thymus of puppies infected with the Snyder Hill Strain of canine distemper virus Análise morfométrica do timo de cães filhotes infectados com a amostra Snyder Hill do vírus de cinomose canina

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2006
The thymic morphometry analysis was used for determining apoptosis and atrophy of the thymus of eight puppies inoculated with canine distemper virus (CDV). Three healthy dogs were used as negative controls.
C.M. Alves, A.C. Vasconcelos, A.S. Martins, H.L. del Puerto, F.G.A. Santos, J.E.S. Nunes, P.P. Campos, L. Moro   +7 more
doaj   +1 more source

Identificação de genótipos de Manihot sp. com alelos de resistência ao vírus do Mosaico Africano. [PDF]

, 2012
O vírus do mosaico africano da mandioca (Cassava mosaic disease - CMD) é a virose mais importante da cultura, sendo encontrada na África, Índia, Malásia e Ásia.
FERREIRA, C. F., LEDO, C. A. da S., OLIVEIRA, E. J. de, OLIVEIRA, G. A. F., SILVEIRA, T. C. da, VIEIRA, L. de J.   +5 more
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Promoter Motifs in NCLDVs: An Evolutionary Perspective

Viruses, 2017
For many years, gene expression in the three cellular domains has been studied in an attempt to discover sequences associated with the regulation of the transcription process. Some specific transcriptional features were described in viruses, although few
Graziele Pereira Oliveira, Ana Cláudia dos Santos Pereira Andrade, Rodrigo Araújo Lima Rodrigues, Thalita Souza Arantes, Paulo Victor Miranda Boratto, Ludmila Karen dos Santos Silva, Fábio Pio Dornas, Giliane de Souza Trindade, Betânia Paiva Drumond, Bernard La Scola, Erna Geessien Kroon, Jônatas Santos Abrahão   +11 more
doaj   +1 more source

Az RNS silencing szerepe, mechanizmusa a vírus gazda kölcsönhatásban = The role and the mechanism of RNA silencing in the plant virus interplay [PDF]

, 2009
Az RNS silencing, egy géninaktivációs mechanizmus, amely szinte az összes eukarióta szervezetben működik. Kutatásaink során feltártuk a Cymbidium ringspot vírus genomról kéződő small interferáló (si) RNS eredetét nagy hatékonyságú 454 (Life Science) és ...
Barta, Endre, Burgyán, József, Csorba, Tibor, Giczey, Gábor, Horkics, Angéla Judit, Nagy, Tibor, Pálfy, Tamás Bertalan, Szittya, György, Tóth, Gábor, Válóczi, Anna Róza, Várallyay, Éva   +10 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Comparação de sistemas participativos online com sistemas convencionais na monitorização de epidemia do vírus H1N1 [PDF]

, 2014
Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas MonizO vírus Influenza é responsável por epidemias anuais de gripe, apresentando um elevado potencial pandémico, devido às constantes modificações verificadas na ...
Baptista, David João de Franco Vinha Ferro
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source