Results 41 to 50 of about 296,682 (195)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Suscetibilidade dos vírus da gripe aos antivirais inibidores da neuraminidase em Portugal, 2009-2014 [PDF]

, 2014
Os antivirais têm também uma longa e extensa história no tratamento e prevenção da gripe, sendo hoje uma importante opção para o tratamento da doença, bem como a medida de prevenção de eleição numa fase inicial de uma pandemia.
Conde, Patrícia, Cristóvão, Paula, Furtado, Cristina, Guiomar, Raquel, Maia, Ana Carina, Pechirra, Pedro   +5 more
core  

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Linking influenza virus tissue tropism to population-level reproductive fitness.

PLoS ONE, 2012
Influenza virus tissue tropism defines the host cells and tissues that support viral replication and contributes to determining which regions of the respiratory tract are infected in humans. The location of influenza virus infection along the respiratory
Leslie A Reperant, Thijs Kuiken, Bryan T Grenfell, Albert D M E Osterhaus, Andrew P Dobson   +4 more
doaj   +1 more source

Programa Nacional de Vigilância da Gripe: relatório da época 2017/2018 [PDF]

, 2018
A vigilância da gripe em Portugal através do Programa Nacional de Vigilância da Gripe permite monitorizar, descrever a atividade gripal, detetar e identificar os vírus da gripe em circulação. O programa integra as componentes de vigilância clínica e
Conde, Patrícia, Costa, Inês, Cristóvão, Paula, Guiomar, Raquel, Machado, Ausenda, Pechirra, Pedro, Rodrigues, Ana Paula, Silva, Susana, Torres, Ana Rita   +8 more
core   +1 more source

Efetividade da vacina antigripal na época 2010-2011 em Portugal: resultados do projeto EuroEVA [PDF]

, 2012
Objetivos: O estudo EuroEVA (Efetividade da vacina antrigripal na Europa) teve como objetivos estimar a efetividade da vacina antigripal sazonal 2010-2011 na população geral e nos indivíduos com 65 ou mais anos de idade.
Batista, Inês, Conde, Patrícia, Falcão, Isabel, Gonçalves, Paulo, Guiomar, Raquel, Machado, Ausenda, Marinho Falcão, José, Nunes, Baltazar, Pechirra, Pedro   +8 more
core   +2 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Cryptoporus volvatus extract inhibits influenza virus replication in vitro and in vivo.

PLoS ONE, 2014
Influenza virus is the cause of significant morbidity and mortality, posing a serious health threat worldwide. Here, we evaluated the antiviral activities of Cryptoporus volvatus extract on influenza virus infection.
Li Gao, Yipeng Sun, Jianyong Si, Jinhua Liu, Guibo Sun, Xiaobo Sun, Li Cao   +6 more
doaj   +1 more source

Vigilância da Gripe em Portugal no inverno 2013/2014 [PDF]

, 2014
Introdução: O Programa Nacional de Vigilância da Gripe tem como objetivos: recolha, análise e divulgação da informação sobre a atividade gripal em Portugal.
Carpinteiro, Dina, Conde, Patrícia, Cristóvão, Paula, Guiomar, Raquel, Maia, Ana Carina, Nunes, Baltazar, Pechirra, Pedro, Roque, Carla, Sampaio, Daniel A.   +8 more
core  

Combinatorial Synthesis of Next Generation Water‐Soluble Quaternized N‐Halamine Oligomers with Long‐Lasting Antiviral Properties

Advanced Functional Materials, EarlyView.
A combinatorial library of dual‐functional antiviral oligomers incorporating N‐halamine and quaternary ammonium functionalities is developed for long‐lasting antiviral activity. The lead materials exhibit rapid and durable antiviral activity against SARS‐CoV‐2 variants and influenza H1N1, with 4 to 5 log reduction in viral copies at 5 mg mL−1 ...
Eid Nassar‐Marjiya, Konda Reddy Kunduru, Krishanu Ghosal, Luna Rizik, Nofar Atari, Mahran Daifa, Neta Kutner, Bassma Khamaisi, Qi Wu, Simran Jindal, Merna Shaheen‐Mualim, Ranabir Majumder, Mahitosh Mandal, Michal Mandelboim, Shady Farah   +14 more
wiley   +1 more source