Results 121 to 130 of about 9,362,172 (272)

Cytosolic Glucosylceramide regulates endolysosomal function in Niemann-Pick type C disease [PDF]

, 2019
A new paradigm for Niemann-Pick C disease is presented where lysosomal storage leads to a deficit in cytoplasmic glucosylceramide (GlcCer) where it performs important functions.
Bhardwaj, Meenakshi, Haberkant, Per, Schmid, Ralf, Sillence, Daniel J., Tongue, Paige, Wheeler, S.   +5 more
core   +1 more source

Lysosomal dysfunction by inactivation of V-ATPase drives innate immune response in C. elegans

Cell Reports
Summary: Pathogens target vacuolar ATPase (V-ATPase) to inhibit lysosomal acidification or lysosomal fusion, causing lysosomal dysfunction. However, it remains unknown whether cells can detect dysfunctional lysosomes and initiate an immune response.
Xuepiao Pu, Bin Qi
doaj   +1 more source

DNA polymerase V activity is autoregulated by a novel intrinsic DNA-dependent ATPase

eLife, 2014
Escherichia coli DNA polymerase V (pol V), a heterotrimeric complex composed of UmuD′2C, is marginally active. ATP and RecA play essential roles in the activation of pol V for DNA synthesis including translesion synthesis (TLS). We have established three
Aysen L Erdem, Malgorzata Jaszczur, Jeffrey G Bertram, Roger Woodgate, Michael M Cox, Myron F Goodman   +5 more
doaj   +1 more source

Activation of PI3K, Akt, and ERK during early rotavirus infection leads to V-ATPase-dependent endosomal acidification required for uncoating

PLoS Pathogens, 2018
The cellular PI3K/Akt and/or MEK/ERK signaling pathways mediate the entry process or endosomal acidification during infection of many viruses. However, their roles in the early infection events of group A rotaviruses (RVAs) have remained elusive.
Mahmoud Soliman, J. Seo, Deok-Song Kim, Ji-Yun Kim, Jun-Gyu Park, M. M. Alfajaro, Yeong-Bin Baek, Eun-Hyo Cho, J. Kwon, Jong-Soon Choi, Mun-Il Kang, Sang-Ik Park, Kyoung-Oh Cho   +12 more
semanticscholar   +1 more source

Isoform-specific gene disruptions reveal a role for the V-ATPase subunit a4 isoform in the invasiveness of 4T1-12B breast cancer cells

Journal of Biological Chemistry, 2019
The vacuolar H+-ATPase (V-ATPase) is an ATP-driven proton pump present in various intracellular membranes and at the plasma membrane of specialized cell types.
C. McGuire, Michaela Collins, G. Sun-Wada, Y. Wada, M. Forgac   +4 more
semanticscholar   +1 more source

secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila [PDF]

, 2019
Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products.
Dent, J., Drapeau, P., Feingold, D., Knogler, L., Nilson, L., O'Donnell, M., Starc, T.   +6 more
core   +2 more sources

Functional coupling of V-ATPase and CLC-5

World Journal of Nephrology, 2017
Dent's disease is an X-linked renal tubulopathy characterized by low molecular weight proteinuria, hypercalciuria and progressive renal failure. Disease aetiology is associated with mutations in the CLCN5 gene coding for the electrogenic 2Cl-/H+ antiporter chloride channel 5 (CLC-5), which is expressed in the apical endosomes of renal proximal tubules ...
Kyoji Moriya, George Seki, Nobuhiko Satoh, Shoko Horita, Motonobu Nakamura, Atsushi Suzuki, Masashi Suzuki   +6 more
openaire   +2 more sources

Identification and Functional Analysis of V-ATPaseA and C Genes in Hyphantria cunea

Insects
Vacuolar (H+)-ATPases (V-ATPases) are ATP-driven proton pumps that play multifaceted roles across various organisms. Despite their widespread significance, the functional implications of V-ATPase genes in Hyphantria cunea, an invasive forest pest with a ...
Xiaojie Wang, Dan Zhao, Qian Wang, Yanan Liu, Xiujun Lu, Wei Guo   +5 more
doaj   +1 more source

The Inhibitory Effect of Celangulin V on the ATP Hydrolytic Activity of the Complex of V-ATPase Subunits A and B in the Midgut of Mythimna separata

Toxins, 2019
Celangulin V (CV) is a compound isolated from Celastrus angulatus Max that has a toxic activity against agricultural insect pests. CV can bind to subunits a, H, and B of the vacuolar ATPase (V-ATPase) in the midgut epithelial cells of insects.
Liwen Ding, Zongxin Guo, Hang Xu, Tie Li, Yuanyuan Wang, Hu Tao   +5 more
doaj   +1 more source

コウボ エキホウマク ATPase ノ コウゾウ ト キノウ [PDF]

, 2005
The yeast vacuolar membrane H+-ATPase (V-ATPase) is the first member of "vacuolar type" ATPase family that has been successively identified in various endocytic and exocytic membrane compartments of eukaryotic cells.
Yasuhiro Anraku, 安楽 泰宏, 帝京科学大学理工学部バイオサイエンス学科   +2 more
core