Results 161 to 170 of about 156,233 (327)

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, EarlyView.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

Luminal acidification of diverse organelles by V-ATPase in animal cells [PDF]

, 2000
Eukaryotic cells contain organelles bounded by a single membrane in the cytoplasm. These organelles have differentiated to carry out various functions in the pathways of endocytosis and exocytosis. Their lumina are acidic, with pH ranging from 4.5 to 6.5.
Futai, Masamitsu, Kanazawa, Hiroshi, Moriyama, Yoshinori, Oka, Toshihiko, Sun-Wada, Ge-hong, Wada, Yoh   +5 more
core  

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

The expression of ABCG4, V-ATPase and clinic significance of their correlation with NSCLC

Chinese Journal of Lung Cancer, 2008
Background and objective It has been proven that the multiple drug resistance is main reason for failure of chemotherapy in lung cancers and ABC transporter play a main role for chemoresistance in mediating drug efflux.
Zhipei ZHANTG, Xiaofei LI, Xiaoping WANG, Yongan ZHOU, Hong XU, Jian WANG, Lijun HUANG, Yutu TIAN, Qingshu CHENG   +8 more
doaj  

Diphyllin, a Novel and Naturally Potent V-ATPase Inhibitor, Abrogates Acidification of the Osteoclastic Resorption Lacunae and Bone Resorption [PDF]

, 2007
Mette G Sørensen, Kim Henriksen, A.V. Neutzsky-Wulff, Morten Hanefeld Dziegiel, M.A. Karsdal   +4 more
openalex   +1 more source

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source

V-ATPase E mediates Cry2Ab binding and toxicity in Helicoverpa armigera [PDF]

, 2023
Yuge Zhao, Pin Li, Xue Yao, Y. Robert Li, Yu Tian, Guiying Xie, Zhongyuan Deng, Shuxia Xu, Jizhen Wei, Xianchun Li, Shiheng An   +10 more
openalex   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

3P154 Rotor-Stator Interactions in V1 and Vo from Enterococcus hirae V-ATPase(Molecular motor,Poster,The 52th Annual Meeting of the Biophysical Society of Japan(BSJ2014))

, 2014
Hiroshi Ueno, Yoshihiro Minagawa, Mayu Hara, Ichiro Yamato, Hiroyuki Noji, Murata Takeshi, Ryota Iino, Eiro Muneyuki   +7 more
openalex   +2 more sources

A Novel Insect V-ATPase Subunit M9.7 Is Glycosylated Extensively [PDF]

, 1999
Hans Merzendorfer, Markus Huss, Roland Schmid, William R. Harvey, Helmut Wieczorek   +4 more
openalex   +1 more source