Results 251 to 260 of about 9,362,172 (272)

Emerging insights on the role of V‐ATPase in human diseases: Therapeutic challenges and opportunities

Medicinal research reviews (Print), 2021
The control of the intracellular pH is vital for the survival of all organisms. Membrane transporters, both at the plasma and intracellular membranes, are key players in maintaining a finely tuned pH balance between intra‐ and extracellular spaces, and ...
Cátia Santos-Pereira, L. Rodrigues, M. Côrte-Real   +2 more
semanticscholar   +1 more source

Physiology of V-ATPases [PDF]

Journal of Experimental Biology, 1992
ABSTRACT Protons migrate much faster than other ions through water, ice and water-lined membrane channels because they participate in hydrogen bonding and H+H2O exchange. Similarly, hydrogen bonding enables protons with amino, carbonyl, phosphoryl and sulfonyl residues to influence critically the charge, conformation and stability of ...
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Biochemistry of the renal V-ATPase

Journal of Experimental Biology, 1992
ABSTRACT In most eukaryotic cells, vacuolar H+-ATPases (V-ATPases) are present primarily or exclusively in intracellular membrane compartments, functioning in the acidification of the endocytic and secretory vacuolar apparatus necessary for constitutive cell function. V-ATPases also participate in renal hydrogen ion secretion in both the
Xiao-Li Guo, Kun Zhang, Raoul D. Nelson, Zhi-Qiang Wang, Beth S. Lee, Stephen L. Gluck, Ji-Yi Fu   +6 more
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Structure and Regulation of the V-ATPases

Journal of Bioenergetics and Biomembranes, 2005
The V-ATPases are ATP-dependent proton pumps present in both intracellular compartments and the plasma membrane. They function in such processes as membrane traffic, protein degradation, renal acidification, bone resorption and tumor metastasis. The V-ATPases are composed of a peripheral V(1) domain responsible for ATP hydrolysis and an integral V(0 ...
Jie Qi, Michael Forgac, Kevin C. Jefferies, Ayana Hinton, Takao Inoue, Yanru Wang   +5 more
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V-ATPases as Drug Targets

Journal of Bioenergetics and Biomembranes, 2005
V-ATPases are large, complex enzymes responsible for acidification of many internal compartments in eukaryotic cells. They also occur on plasma membranes of specialized cells, where they acidify the surrounding milieu. Numerous physiological processes depend on the activity of V-ATPases, and V-ATPases are implicated as a contributing factor in multiple
Emma Jean Bowman, Barry J. Bowman
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V-ATPases in phagocytic cells

Journal of Experimental Biology, 1992
ABSTRACT V-ATPases in phagocytic cells are known to mediate the acidification of most intracellular organelles. Proton-pump-mediated acidification of these organellar compartments is vital to numerous cell processes, including receptor recycling, protein processing and sorting and microbial degradation.
Ori D. Rotstein, Sergio Grinstein, Gergely L. Lukacs, Arvind Nanda   +3 more
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High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles

Science
Intercellular communication in the nervous system occurs through the release of neurotransmitters into the synaptic cleft between neurons. In the presynaptic neuron, the proton pumping vesicular- or vacuolar-type ATPase (V-ATPase) powers neurotransmitter
Claire E. Coupland, Ryan Karimi, S. Bueler, Yingke Liang, G. M. Courbon, Justin M. Di Trani, Cassandra J. Wong, Rayan Saghian, Ji-Young Youn, Lu-Yang Wang, J. Rubinstein   +10 more
semanticscholar   +1 more source

Structure and Assembly of the Yeast V-ATPase

Journal of Bioenergetics and Biomembranes, 2003
The yeast V-ATPase belongs to a family of V-type ATPases present in all eucaryotic organisms. In Saccharomyces cerevisiae the V-ATPase is localized to the membrane of the vacuole as well as the Golgi complex and endosomes. The V-ATPase brings about the acidification of these organelles by the transport of protons coupled to the hydrolysis of ATP.
Tom H. Stevens, Andrew R. Flannery, Laurie A. Graham   +2 more
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The V-ATPase in insect epithelia

Journal of Experimental Biology, 2017
![Figure][1] Mike O'Donnell discusses the impact of two classic papers, published by Helmut Wieczorek in Journal of Biological Chemistry in 1989 and 1991, which report the discovery of the the insect midgut V-ATPase.
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The V-ATPase as a Target for Antifungal Drugs

Current Protein & Peptide Science, 2012
The ubiquitous and essential V-ATPase is a worthy chemotherapeutic target in the escalating battle against invasive fungal infections. Pathogenic fungi require optimum V-ATPase function for secretion of virulence factors, induction of stress response pathways, hyphal morphology and homeostasis of pH and other cations in order to successfully survive ...
Rajini Rao, Yongqiang Zhang
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