Results 261 to 270 of about 9,362,172 (272)

Evolution and isoforms of V-ATPase subunits

Journal of Experimental Biology, 1992
ABSTRACT The structure of V- and F-ATPases/ATP synthases is remarkably conserved throughout evolution. Sequence analyses show that the V- and F-ATPases evolved from the same enzyme that was already present in the last common ancestor of all known extant life forms.
Thomas Starke, Johann Peter Gogarten, J Fishman, Henrik Kibak, L Taiz   +4 more
openaire   +2 more sources

V-ATPases of the plasma membrane

Journal of Experimental Biology, 1992
ABSTRACT V-ATPases reside in high densities on the plasma membrane in specialized types of insect and vertebrate cells. They provide unique biochemical and electrophysiological properties that allow them to function in energizing the plasma membrane in insects, and in cellular acid excretion in vertebrates.
openaire   +2 more sources

Evolution of structure and function of V-ATPases

Journal of Bioenergetics and Biomembranes, 1992
Proton pumping ATPases/ATPsynthases are found in all groups of present-day organisms. The structure of V- and F-type ATPases/ATP synthases is very conserved throughout evolution. Sequence analysis shows that the V- and F-type ATPases evolved from the same enzyme already present in the last common ancestor of all known extant life forms.
P Bernasconi, Johann Peter Gogarten, Henrik Kibak, Thomas Starke, Lincoln Taiz   +4 more
openaire   +3 more sources

V-ATPases in Insects

1995
Insects are one of the most successful classes of organism in the world. Their small size, impermeable exocuticle and short generation times have allowed them to adapt to exploit a huge range of ecological niches, many of which place them in conflict with humans.
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V-ATPase as an effective therapeutic target for sarcomas

Experimental Cell Research, 2014
Malignant tumors show intense glycolysis and, as a consequence, high lactate production and proton efflux activity. We investigated proton dynamics in osteosarcoma, rhabdomyosarcoma, and chondrosarcoma, and evaluated the effects of esomeprazole as a therapeutic agent interfering with tumor acidic microenvironment.
Perut F, AVNET, SOFIA, FOTIA, CATERINA, Baglìo SR, SALERNO, MANUELA, Hosogi S, Kusuzaki K, BALDINI, NICOLA   +7 more
openaire   +4 more sources

ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy

Nature Structural & Molecular Biology, 2022
Yue Xu, Sen Cheng, H. Zeng, Ping Zhou, Yan Ma, Lin Li, Xiaoyun Liu, Feng Shao, Jing Ding   +8 more
semanticscholar   +1 more source

Regulation of the mammalian-brain V-ATPase through ultraslow mode-switching

Nature, 2022
Eleftherios Kosmidis, C. Shuttle, Julia Preobraschenski, Marcelo Ganzella, Peter J. Johnson, Salome Veshaguri, Jesper Holmkvist, Mads P. Møller, O. Marantos, F. Marcoline, M. Grabe, Jesper L. Pedersen, R. Jahn, D. Stamou   +13 more
semanticscholar   +1 more source

V-ATPase functions in normal and disease processes

Pflügers Archiv - European Journal of Physiology, 2007
Eukaryotic cells have evolved a family of ATP-dependent proton pumps known as the vacuolar (H(+))-ATPases (or V-ATPases) to regulate the pH of intracellular compartments, the extracellular space, and the cytoplasm. V-ATPases present within intracellular compartments are important for such normal cellular processes as receptor-mediated endocytosis and ...
Michael Forgac, Sarah Bond, Ayana Hinton
openaire   +3 more sources

Novel V-ATPase inhibitors

GBM Annual Spring meeting Mosbach 2005, 2005
Helmut Wieczorek, Florenz Sasse, Brigitte Kunze, Markus Huss, Gudrun Ingenhorst, Axel Zeeck   +5 more
openaire   +2 more sources

Electron cryomicroscopy observation of rotational states in a eukaryotic V-ATPase

Nature, 2015
Jianhua Zhao, S. Benlekbir, J. Rubinstein   +2 more
semanticscholar   +1 more source