Results 61 to 70 of about 9,362,172 (272)

The V-ATPases in cancer and cell death

Cancer Gene Therapy, 2022
Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases, also known as H+-ATPases, are large multi-subunit protein complexes composed of a peripheral domain (V1) responsible for the hydrolysis of ATP and a membrane-integrated domain (V0 ...
Fangquan Chen, Rui Kang, Jiao Liu, Daolin Tang   +3 more
openaire   +2 more sources

RNA Interference of Genes Encoding the Vacuolar-ATPase in Liriomyza trifolii

Insects, 2021
The leafminer fly, Liriomyza trifolii, is an invasive pest of vegetable and horticultural crops in China. In this study, a microinjection method based on dsRNA was developed for RNA interference (RNAi) in L. trifolii using genes encoding vacuolar-ATPase (
Ya-Wen Chang, Yu-Cheng Wang, Xiao-Xiang Zhang, Junaid Iqbal, Yu-Zhou Du   +4 more
doaj   +1 more source

Regulation of proton-translocating V-ATPases [PDF]

Journal of Experimental Biology, 1997
ABSTRACT Vacuolar-type ATPases (V-ATPases) are proton-translocating enzymes that occur in the endomembranes of all eukaryotes and in the plasma membranes of many eukaryotes. They are multisubunit, heteromeric proteins composed of two structural domains, a peripheral, catalytic V1 domain and a membrane-spanning Vo domain.
Hans Merzendorfer, Ralph Gräf, Helmut Wieczorek, William R. Harvey, M Huss   +4 more
openaire   +3 more sources

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

Cancer Medicine, 2018
Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps protons across intracellular and plasma membranes. It consists of a large multi‐subunit protein complex and influences a wide range of cellular processes.
Bradleigh Whitton, Haruko Okamoto, Graham Packham, Simon J. Crabb   +3 more
doaj   +1 more source

Rag GTPases are cardioprotective by regulating lysosomal function. [PDF]

, 2014
The Rag family proteins are Ras-like small GTPases that have a critical role in amino-acid-stimulated mTORC1 activation by recruiting mTORC1 to lysosome.
Guan, Kun-Liang, Jewell, Jenna L, Kim, Young Chul, Mo, Jung-Soon, Park, Hyun Woo, Russell, Ryan C, Sadoshima, Junichi, Sciarretta, Sebastiano, Wu, Xiaohui   +8 more
core   +2 more sources

Immunolocalization of IP3R and V-ATPase in Ameloblastomas [PDF]

Head and Neck Pathology, 2019
The goal of this study was to investigate the immunolocalization of inositol 1,4,5-trisphosphate receptor (IP3R) and vacuolar ATPase (V-ATPase) in ameloblastomas with special attention to the invasive front. Thirty-seven cases of previously diagnosed formalin-fixed paraffin-embedded (FFPE) human ameloblastoma samples were selected for this study.
Allan Fernando Giovanini, Thaynara Fernanda Priesnitz, Bruna Til, Gisele Reisdoerfer, Tuanny Carvalho de Lima do Nascimento, Bernardo Sobreiro, Adriane Sousa de Siqueira, João de Jesus Viana Pinheiro   +7 more
openaire   +3 more sources

Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster [PDF]

, 2016
In vertebrates, TFEB (transcription factor EB) and MITF (microphthalmia-associated transcription factor) family of basic Helix-Loop-Helix (bHLH) transcription factors regulates both lysosomal function and organ development.
Busi, Ilaria, De Masi, Federico, Fumagalli, Arianna, Kobia, Francis, Tognon, Emiliana, Vaccari, Thomas   +5 more
core   +3 more sources

Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2016
V-ATPases are ATP-driven proton pumps that function within both intracellular compartments and the plasma membrane in a wide array of normal physiological and pathophysiological processes. V-ATPases are composed of a peripheral V(1) domain that hydrolyzes ATP and an integral V(0) domain that transports protons.
Laura A. Stransky, Christina McGuire, Michael Forgac, Kristina Cotter   +3 more
openaire   +3 more sources

Regulation and Isoform Function of the V-ATPases [PDF]

Biochemistry, 2010
The vacuolar (H(+))-ATPases are ATP-dependent proton pumps that acidify intracellular compartments and, in some cases, transport protons across the plasma membrane of eukaryotic cells. Intracellular V-ATPases play an important role in normal physiological processes such as receptor-mediated endocytosis, intracellular membrane trafficking, pro-hormone ...
Regina Saum, Masashi Toei, Michael Forgac   +2 more
openaire   +3 more sources

Mutations in the V‐ATPase Assembly Factor VMA21 Cause a Congenital Disorder of Glycosylation With Autophagic Liver Disease

Hepatology, 2020
Vacuolar H+‐ATP complex (V‐ATPase) is a multisubunit protein complex required for acidification of intracellular compartments. At least five different factors are known to be essential for its assembly in the endoplasmic reticulum (ER).
M. Cannata Serio, Laurie A. Graham, A. Ashikov, Lars Elmann Larsen, K. Raymond, S. Timal, Gwenn Le Meur, M. Ryan, E. Czarnowska, Jos C. Jansen, M. He, C. Ficicioglu, P. Pichurin, Linda Hasadsri, B. Minassian, Alessandra Rugierri, H. Kalimo, W. A. Rios-Ocampo, C. Gilissen, R. Rodenburg, J. W. Jonker, A. Holleboom, E. Morava, J. Veltman, P. Socha, Tom H. Stevens, M. Simons, D. Lefeber   +27 more
semanticscholar   +1 more source