Results 41 to 50 of about 156,998 (303)

Expansion of Thaumarchaeota habitat range is correlated with horizontal transfer of ATPase operons. [PDF]

, 2019
Thaumarchaeota are responsible for a significant fraction of ammonia oxidation in the oceans and in soils that range from alkaline to acidic. However, the adaptive mechanisms underpinning their habitat expansion remain poorly understood.
Bartlett, Douglas H, Eloe-Fadrosh, Emiley A, Hall, Richard, Han, Ping, Heiner, Cheryl, Herbold, Craig W, Huang, Li, Ingalls, Anitra E, Ji, Junbin, Jia, Zhongjun, Jung, Man-Young, Li, Meng, Liu, Linmeng, Liu, Yang, Lu, Lu, Martens-Habbena, Willm, Qin, Wei, Ren, Yi, Rhee, Sung-Keun, Stahl, David A, Wagner, Michael, Wang, Baozhan, Yan, Xin, Zheng, Yue, Zhou, Xue   +24 more
core   +2 more sources

V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis

Theranostics, 2018
Vacuolar ATPases (V-ATPases) play a critical role in regulating extracellular acidification of osteoclasts and bone resorption. The deficiencies of subunit a3 and d2 of V-ATPases result in increased bone density in humans and mice. One of the traditional drug design strategies in treating osteoporosis is the use of subunit a3 inhibitor. Recent findings
Duan, Xiaohong, Yang, Shaoqing, Zhang, Lei, Yang, Tielin   +3 more
openaire   +2 more sources

Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2016
V-ATPases are ATP-driven proton pumps that function within both intracellular compartments and the plasma membrane in a wide array of normal physiological and pathophysiological processes. V-ATPases are composed of a peripheral V(1) domain that hydrolyzes ATP and an integral V(0) domain that transports protons.
Christina, McGuire, Kristina, Cotter, Laura, Stransky, Michael, Forgac   +3 more
openaire   +3 more sources

The curious case of vacuolar ATPase: regulation of signaling pathways

Molecular Cancer, 2018
The Vacuolar ATPase (V-ATPase) is a proton pump responsible for controlling the intracellular and extracellular pH of cells. The structure of V-ATPase has been highly conserved among all eukaryotic cells and is involved in diverse functions across ...
Sahithi Pamarthy, Arpita Kulshrestha, Gajendra K. Katara, Kenneth D. Beaman   +3 more
doaj   +1 more source

Rapid purification of human lysosomal membranes, characterisation of the detergent resistent microdomains, purification and reconstitution of the vacuolar proton pump (V-ATPase) [PDF]

, 2006
The lysosomal membrane is a dynamic environment where specific interactions among proteins and between proteins and lipids occur. These interactions are necessary for the proper functioning of the lysosomal apparatus that allows the passage of molecules ...
Chandramohanadas, Rajesh, Hasilik, Andrej (Prof. Dr.)   +1 more
core   +1 more source

The Function of V-ATPases in Cancer [PDF]

Physiological Reviews, 2016
The vacuolar ATPases (V-ATPases) are a family of proton pumps that couple ATP hydrolysis to proton transport into intracellular compartments and across the plasma membrane. They function in a wide array of normal cellular processes, including membrane traffic, protein processing and degradation, and the coupled transport of small molecules, as well as ...
Laura, Stransky, Kristina, Cotter, Michael, Forgac   +2 more
openaire   +2 more sources

RNA Interference of Genes Encoding the Vacuolar-ATPase in Liriomyza trifolii

Insects, 2021
The leafminer fly, Liriomyza trifolii, is an invasive pest of vegetable and horticultural crops in China. In this study, a microinjection method based on dsRNA was developed for RNA interference (RNAi) in L. trifolii using genes encoding vacuolar-ATPase (
Ya-Wen Chang, Yu-Cheng Wang, Xiao-Xiang Zhang, Junaid Iqbal, Yu-Zhou Du   +4 more
doaj   +1 more source

The South American fruit fly : an important pest insect with RNAi-sensitive larval stages [PDF]

, 2019
RNA interference (RNAi) technology has been used in the development of approaches for pest control. The presence of some essential genes, the so-called "core genes," in the RNAi machinery is crucial for its efficiency and robust response in gene ...
Cagliari, Deise, Dias, Nayma, Kremer, Frederico Schmitt, Nava, Dori Edson, Rickes, Leticia Neutzling, Smagghe, Guy, Zotti, Moises   +6 more
core   +1 more source

Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy [PDF]

, 2016
Autophagy is an evolutionarily conserved catabolic process by which cells degrade intracellular proteins and organelles in the lysosomes. Canonical autophagy requires all autophagy proteins (ATGs), whereas noncanonical autophagy is activated by diverse ...
Cai, Xinran, Chen, Xiaoyun, Fu, Yuanyuan, Gao, Ying, Hong, Liang, Huang, Heqing, Li, Min, Li, Sitong, Lin, Yujie, Liu, Peiqing, Liu, Xingguo, Liu, Yajun, Vogt, Andreas, Wen, Weijie, Yang, Zuolong, Yin, Xiao-Ming   +15 more
core   +1 more source

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

Cancer Medicine, 2018
Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps protons across intracellular and plasma membranes. It consists of a large multi‐subunit protein complex and influences a wide range of cellular processes.
Bradleigh Whitton, Haruko Okamoto, Graham Packham, Simon J. Crabb   +3 more
doaj   +1 more source