Results 41 to 50 of about 10,440,305 (287)

The curious case of vacuolar ATPase: regulation of signaling pathways

Molecular Cancer, 2018
The Vacuolar ATPase (V-ATPase) is a proton pump responsible for controlling the intracellular and extracellular pH of cells. The structure of V-ATPase has been highly conserved among all eukaryotic cells and is involved in diverse functions across ...
Sahithi Pamarthy, Arpita Kulshrestha, Gajendra K. Katara, Kenneth D. Beaman   +3 more
doaj   +1 more source

Loss of the V-ATPase B1 subunit isoform expressed in non-neuronal cells of the mouse olfactory epithelium impairs olfactory function. [PDF]

PLoS ONE, 2012
The vacuolar proton-pumping ATPase (V-ATPase) is the main mediator of intracellular organelle acidification and also regulates transmembrane proton (H(+)) secretion, which is necessary for an array of physiological functions fulfilled by organs such as ...
Teodor G Păunescu, Steven Rodriguez, Eric Benz, Mary McKee, Robert Tyszkowski, Mark W Albers, Dennis Brown   +6 more
doaj   +1 more source

Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis

Molecular Metabolism, 2021
Objective: The diabetic heart is characterized by extensive lipid accumulation which often leads to cardiac contractile dysfunction. The underlying mechanism involves a pivotal role for vacuolar-type H+-ATPase (v-ATPase, functioning as endosomal ...
Shujin Wang, Francesco Schianchi, Dietbert Neumann, Li-Yen Wong, Aomin Sun, Frans A. van Nieuwenhoven, Maurice P. Zeegers, Agnieszka Strzelecka, Umare Col, Jan F.C. Glatz, Miranda Nabben, Joost J.F.P. Luiken   +11 more
doaj   +1 more source

Immunolocalization of IP3R and V-ATPase in Ameloblastomas [PDF]

Head and Neck Pathology, 2019
The goal of this study was to investigate the immunolocalization of inositol 1,4,5-trisphosphate receptor (IP3R) and vacuolar ATPase (V-ATPase) in ameloblastomas with special attention to the invasive front. Thirty-seven cases of previously diagnosed formalin-fixed paraffin-embedded (FFPE) human ameloblastoma samples were selected for this study.
Allan Fernando Giovanini, Thaynara Fernanda Priesnitz, Bruna Til, Gisele Reisdoerfer, Tuanny Carvalho de Lima do Nascimento, Bernardo Sobreiro, Adriane Sousa de Siqueira, João de Jesus Viana Pinheiro   +7 more
openaire   +2 more sources

Defining steps in RAVE-catalyzed V-ATPase assembly using purified RAVE and V-ATPase subcomplexes [PDF]

Journal of Biological Chemistry, 2021
The vacuolar H+-ATPase (V-ATPase) is a highly conserved proton pump responsible for the acidification of intracellular organelles in virtually all eukaryotic cells. V-ATPases are regulated by the rapid and reversible disassembly of the peripheral V1 domain from the integral membrane Vo domain, accompanied by release of the V1 C subunit from both ...
Michael C. Jaskolka, Maureen Tarsio, Anne M. Smardon, Md. Murad Khan, Patricia M. Kane   +4 more
openaire   +2 more sources

The illustration of V-ATPase and ECDD-S16 interaction.

, 2023
(A) Image depicts the binding between ECDD-S16 and V-ATPase V0 region. (B) A close-up view of the binding pocket between V-ATPase and ECDD-S16 illustrates the location of neighboring amino acids around ECDD-S16.
Napason Chabang (17457772), Pongsak Utaisincharoen (5394845), Marisa Ponpuak (4230337), Thanapon Charoenwongpaiboon (9542504), Patoomratana Tuchinda (1619206), Suparerk Borwornpinyo (3509102), Peeraya Ekchariyawat (3911113), Rattatammanoon Saengfak (17457757), Chularat Luangjindarat (17457766), Sucharat Sanongkiet (2370640), Matsayapan Pudla (534719), Supaporn Mala (17457763), Sitthivut Charoensutthivarakul (1283955), Suphasuta Khongpraphan (17457760), Bumrung Munyoo (17457769)   +14 more
core   +1 more source

HCO3−-independent pH Regulation in Astrocytes in Situ Is Dominated by V-ATPase

, 2015
The mechanisms of HCO3−-independent intracellular pH (pHi) regulation were examined in fibrous astrocytes within isolated neonatal rat optic nerve (RON) and in cultured cortical astrocytes.
R. Fern (7680761), M. Salter (7680758), D. B. Hansen (7680752), Nestor Garrido-Comas (7680755)   +3 more
core   +3 more sources

RNA Interference of Genes Encoding the Vacuolar-ATPase in Liriomyza trifolii

Insects, 2021
The leafminer fly, Liriomyza trifolii, is an invasive pest of vegetable and horticultural crops in China. In this study, a microinjection method based on dsRNA was developed for RNA interference (RNAi) in L. trifolii using genes encoding vacuolar-ATPase (
Ya-Wen Chang, Yu-Cheng Wang, Xiao-Xiang Zhang, Junaid Iqbal, Yu-Zhou Du   +4 more
doaj   +1 more source

Regulation of proton-translocating V-ATPases [PDF]

Journal of Experimental Biology, 1997
ABSTRACT Vacuolar-type ATPases (V-ATPases) are proton-translocating enzymes that occur in the endomembranes of all eukaryotes and in the plasma membranes of many eukaryotes. They are multisubunit, heteromeric proteins composed of two structural domains, a peripheral, catalytic V1 domain and a membrane-spanning Vo domain.
H, Merzendorfer, R, Gräf, M, Huss, W R, Harvey, H, Wieczorek   +4 more
openaire   +2 more sources

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

Cancer Medicine, 2018
Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps protons across intracellular and plasma membranes. It consists of a large multi‐subunit protein complex and influences a wide range of cellular processes.
Bradleigh Whitton, Haruko Okamoto, Graham Packham, Simon J. Crabb   +3 more
doaj   +1 more source