Results 61 to 70 of about 10,440,305 (287)

Specific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivoResearch in context

EBioMedicine, 2019
Background: Cancer cells use specific V-ATPase subunits to activate oncogenic pathways. Therefore, we investigated V-ATPase deregulation in aggressive gliomas and associated signaling.
Andrea Terrasi, Irene Bertolini, Cristina Martelli, Gabriella Gaudioso, Andrea Di Cristofori, Alessandra Maria Storaci, Miriam Formica, Silvano Bosari, Manuela Caroli, Luisa Ottobrini, Thomas Vaccari, Valentina Vaira   +11 more
doaj   +1 more source

RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification

Frontiers in Cell and Developmental Biology, 2021
The yeast RAVE (Regulator of H+-ATPase of Vacuolar and Endosomal membranes) complex and Rabconnectin-3 complexes of higher eukaryotes regulate acidification of organelles such as lysosomes and endosomes by catalyzing V-ATPase assembly.
Michael C. Jaskolka, Samuel R. Winkley, Patricia M. Kane   +2 more
doaj   +1 more source

Regulation of V-ATPase Assembly in Nutrient Sensing and Function of V-ATPases in Breast Cancer Metastasis [PDF]

Frontiers in Physiology, 2018
V-ATPases are proton pumps that function to acidify intracellular compartments in all eukaryotic cells, and to transport protons across the plasma membrane of certain specialized cells. V-ATPases function in many normal and disease processes, including membrane traffic, protein degradation, pathogen entry, and cancer cell invasion.
Michael P. Collins, Michael Forgac, Michael Forgac   +2 more
openaire   +3 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

RILP regulates vacuolar ATPase through interaction with the V1G1 subunit [PDF]

, 2014
Rab-interacting lysosomal protein (RILP) is a downstream effector of the Rab7 GTPase. GTP-bound Rab7 recruits RILP to endosomal membranes and, together, they control late endocytic traffic, phagosome and autophagosome maturation and are responsible for ...
Nisi V, Di Fiore PP, BUCCI, Cecilia, Sigismund S, Pascolutti R, De Luca M, Progida C, Cogli L   +7 more
core   +3 more sources

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Advances in targeting the vacuolar proton-translocating ATPase (V-ATPase) for anti-fungal therapy

Frontiers in Pharmacology, 2014
Vacuolar proton-translocating ATPase (V-ATPase) is a membrane-bound, multi-subunit enzyme that uses the energy of ATP hydrolysis to pump protons across membranes. V-ATPase activity is critical for pH homeostasis and organelle acidification as well as for
Summer R. Hayek, Samuel A. Lee, Samuel A. Lee, Karlett J. Parra   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Genomic identification, annotation, and comparative analysis of Vacuolar-type ATP synthase subunits in Diaphorina citri

GigaByte, 2022
The hemipteran insect Diaphorina citri, or Asian citrus psyllid, is a vector for Candidatus Liberibacter asiaticus (CLas), the bacterium causing citrus greening disease, or Huanglongbing (HLB).
Rebecca Grace , Crissy Massimino , Teresa D. Shippy , Will Tank , Prashant S. Hosmani , Mirella Flores-Gonzalez , Lukas A. Mueller , Wayne B. Hunter , Joshua B. Benoit , Susan J. Brown , Tom D’Elia , Surya Saha   +11 more
doaj   +1 more source

I hereby declare that the work presented in this document is based on research carried out by me, and that no part has previously been submitted for a degree in this or any other university [PDF]

, 1995
Inhibitors of known transport processes, in conjunction with ion substitution were used in biochemical, physiological and microelectrode studies to investigate the mechanisms underlying ion and fluid secretion across the Malpighian tubules of Locusta ...
Marshall, Sarah Louise
core