Results 31 to 40 of about 147,751 (260)

F-actin reorganization by V-ATPase inhibition in prostate cancer

Biology Open, 2017
The vacuolar ATPase (V-ATPase) proton pump sustains cellular pH homeostasis, and its inhibition triggers numerous stress responses. However, the cellular mechanisms involved remain largely elusive in cancer cells.
Yamhilette Licon-Munoz, Vera Michel, Colleen A. Fordyce, Karlett J. Parra   +3 more
doaj   +1 more source

Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis

Molecular Metabolism, 2021
Objective: The diabetic heart is characterized by extensive lipid accumulation which often leads to cardiac contractile dysfunction. The underlying mechanism involves a pivotal role for vacuolar-type H+-ATPase (v-ATPase, functioning as endosomal ...
Shujin Wang, Francesco Schianchi, Dietbert Neumann, Li-Yen Wong, Aomin Sun, Frans A. van Nieuwenhoven, Maurice P. Zeegers, Agnieszka Strzelecka, Umare Col, Jan F.C. Glatz, Miranda Nabben, Joost J.F.P. Luiken   +11 more
doaj   +1 more source

Defining steps in RAVE-catalyzed V-ATPase assembly using purified RAVE and V-ATPase subcomplexes [PDF]

Journal of Biological Chemistry, 2021
The vacuolar H+-ATPase (V-ATPase) is a highly conserved proton pump responsible for the acidification of intracellular organelles in virtually all eukaryotic cells. V-ATPases are regulated by the rapid and reversible disassembly of the peripheral V1 domain from the integral membrane Vo domain, accompanied by release of the V1 C subunit from both ...
Michael C. Jaskolka, Maureen Tarsio, Anne M. Smardon, Md. Murad Khan, Patricia M. Kane   +4 more
openaire   +2 more sources

The curious case of vacuolar ATPase: regulation of signaling pathways

Molecular Cancer, 2018
The Vacuolar ATPase (V-ATPase) is a proton pump responsible for controlling the intracellular and extracellular pH of cells. The structure of V-ATPase has been highly conserved among all eukaryotic cells and is involved in diverse functions across ...
Sahithi Pamarthy, Arpita Kulshrestha, Gajendra K. Katara, Kenneth D. Beaman   +3 more
doaj   +1 more source

Loss of the V-ATPase B1 subunit isoform expressed in non-neuronal cells of the mouse olfactory epithelium impairs olfactory function. [PDF]

PLoS ONE, 2012
The vacuolar proton-pumping ATPase (V-ATPase) is the main mediator of intracellular organelle acidification and also regulates transmembrane proton (H(+)) secretion, which is necessary for an array of physiological functions fulfilled by organs such as ...
Teodor G Păunescu, Steven Rodriguez, Eric Benz, Mary McKee, Robert Tyszkowski, Mark W Albers, Dennis Brown   +6 more
doaj   +1 more source

Immunolocalization of IP3R and V-ATPase in Ameloblastomas [PDF]

Head and Neck Pathology, 2019
The goal of this study was to investigate the immunolocalization of inositol 1,4,5-trisphosphate receptor (IP3R) and vacuolar ATPase (V-ATPase) in ameloblastomas with special attention to the invasive front. Thirty-seven cases of previously diagnosed formalin-fixed paraffin-embedded (FFPE) human ameloblastoma samples were selected for this study.
Allan Fernando Giovanini, Thaynara Fernanda Priesnitz, Bruna Til, Gisele Reisdoerfer, Tuanny Carvalho de Lima do Nascimento, Bernardo Sobreiro, Adriane Sousa de Siqueira, João de Jesus Viana Pinheiro   +7 more
openaire   +2 more sources

Regulation of proton-translocating V-ATPases [PDF]

Journal of Experimental Biology, 1997
ABSTRACT Vacuolar-type ATPases (V-ATPases) are proton-translocating enzymes that occur in the endomembranes of all eukaryotes and in the plasma membranes of many eukaryotes. They are multisubunit, heteromeric proteins composed of two structural domains, a peripheral, catalytic V1 domain and a membrane-spanning Vo domain.
H, Merzendorfer, R, Gräf, M, Huss, W R, Harvey, H, Wieczorek   +4 more
openaire   +2 more sources

RNA Interference of Genes Encoding the Vacuolar-ATPase in Liriomyza trifolii

Insects, 2021
The leafminer fly, Liriomyza trifolii, is an invasive pest of vegetable and horticultural crops in China. In this study, a microinjection method based on dsRNA was developed for RNA interference (RNAi) in L. trifolii using genes encoding vacuolar-ATPase (
Ya-Wen Chang, Yu-Cheng Wang, Xiao-Xiang Zhang, Junaid Iqbal, Yu-Zhou Du   +4 more
doaj   +1 more source

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

Cancer Medicine, 2018
Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps protons across intracellular and plasma membranes. It consists of a large multi‐subunit protein complex and influences a wide range of cellular processes.
Bradleigh Whitton, Haruko Okamoto, Graham Packham, Simon J. Crabb   +3 more
doaj   +1 more source

CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7

Life Science Alliance, 2022
The structure of mammalian V-ATPase with mEAK-7 shows how a TLDc domain-containing protein can bind the proton pump to form an activity-sensitive interaction.
Yong Zi Tan, Yazan M Abbas, Jing Ze Wu, Di Wu, Kristine A Keon, Geoffrey G Hesketh, Stephanie A Bueler, Anne-Claude Gingras, Carol V Robinson, Sergio Grinstein, John L Rubinstein   +10 more
doaj   +1 more source