Results 81 to 90 of about 9,362,172 (272)

Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia [PDF]

, 2013
<p>Background Comparative analysis of tissue-specific transcriptomes is a powerful technique to uncover tissue functions. Our FlyAtlas.org provides authoritative gene expression levels for multiple tissues of Drosophila melanogaster (1).
Chintapalli, V.R., Davies, S.A., Dow, J.A.T., Herzyk, P., Wang, J.   +4 more
core   +2 more sources

Advances in targeting the vacuolar proton-translocating ATPase (V-ATPase) for anti-fungal therapy

Frontiers in Pharmacology, 2014
Vacuolar proton-translocating ATPase (V-ATPase) is a membrane-bound, multi-subunit enzyme that uses the energy of ATP hydrolysis to pump protons across membranes. V-ATPase activity is critical for pH homeostasis and organelle acidification as well as for
Summer R. Hayek, Samuel A. Lee, Samuel A. Lee, Karlett J. Parra   +3 more
doaj   +1 more source

Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity

Ecotoxicology and Environmental Safety, 2022
Fluoride is capable of inducing developmental neurotoxicity, yet its mechanisms remain elusive. We aimed to explore the possible role and mechanism of autophagic flux blockage caused by abnormal lysosomal pH in fluoride-induced developmental ...
Xie Han, Yanling Tang, Yuanli Zhang, Jingjing Zhang, Zeyu Hu, Wanjing Xu, Shangzhi Xu, Qiang Niu   +7 more
doaj   +1 more source

Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. [PDF]

, 2019
Autophagy is a lysosomal degradation pathway that eliminates aggregated proteins and damaged organelles to maintain cellular homeostasis. A major route for activating autophagy involves inhibition of the mTORC1 kinase, but current mTORC1-targeting ...
Berdan, Charles A, Chung, Clive Yik-Sham, Ford, Breanna, Nomura, Daniel K, Olzmann, James A, Shin, Hijai R, Ward, Carl C, Zoncu, Roberto   +7 more
core  

Separate roles of PKA and EPAC in renal function unraveled by the optogenetic control of cAMP levels in vivo [PDF]

, 2013
Cyclic AMP (cAMP) is a ubiquitous second messenger that regulates a variety of essential processes in diverse cell types, functioning via cAMP-dependent effectors such as protein kinase A (PKA) and/or exchange proteins directly activated by cAMP (EPAC ...
Akbari, Baillie, Beyenbach, Beyenbach, Bos, Bos, Bos, Brand, Börner, Cabrero, Chepurny, Coast, Coast, Coast, Coast, Dames, Davies, Day, de Rooij, Dow, Dow, Dow, Dow, Enserink, Evans, Gloerich, Guo, Hallows, Hector, Iijima–Ando, Johnson, Johnson, Kalderon, Kandel, Kaufmann, Kaupp, Kerr, Laroche–Joubert, MacPherson, O'Donnell, O'Donnell, Parks, Pastor–Soler, Pastor–Soler, Poulsen, Radford, Rein, Rosay, Ryu, Ryu, Schröder–Lang, Stierl, Stokman, Sözen, Terhzaz, Terhzaz, Torrie, Weissenberger, Wong, Zaccolo, Zaccolo   +60 more
core   +1 more source

Genomic identification, annotation, and comparative analysis of Vacuolar-type ATP synthase subunits in Diaphorina citri

GigaByte, 2022
The hemipteran insect Diaphorina citri, or Asian citrus psyllid, is a vector for Candidatus Liberibacter asiaticus (CLas), the bacterium causing citrus greening disease, or Huanglongbing (HLB).
Rebecca Grace , Crissy Massimino , Teresa D. Shippy , Will Tank , Prashant S. Hosmani , Mirella Flores-Gonzalez , Lukas A. Mueller , Wayne B. Hunter , Joshua B. Benoit , Susan J. Brown , Tom D’Elia , Surya Saha   +11 more
doaj   +1 more source

Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis [PDF]

, 2017
Mutations in the co- chaperone protein, CSPα, cause an autosomal dominant, adult-neuronal ceroid lipofuscinosis (AD-ANCL). The current understanding of CSPα function exclusively at the synapse fails to explain the autophagy-lysosome pathway (ALP ...
Benitez, Bruno A, Sands, Mark S
core   +2 more sources

Mitf is a master regulator of the v-ATPase forming an Mitf/v-ATPase/TORC1 control module for cellular homeostasis [PDF]

Journal of Cell Science, 2015
The v-ATPase is a fundamental eukaryotic enzyme central to cellular homeostasis. Although its impact on key metabolic regulators such as TORC1 is well-documented, our knowledge of mechanisms that regulate v-ATPase activity is limited. Here, we report that the Drosophila transcription factor Mitf is a master regulator of this holoenzyme.
Zhang, T., Zhou, Q., Ogmundsdottir, Margret H, Möller, Katrin, Siddaway, R., Larue, L., Hsing, M., Kong, S. W., Goding, C. R., Palsson, Arnar, Steingrimsson, Eirikur, Pignoni, F.   +11 more
openaire   +4 more sources

Preclinical Evaluation of Ureidosulfamate Carbonic Anhydrase IX/XII Inhibitors in the Treatment of Cancers [PDF]

, 2019
Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Upregulation of the CAIX/XII isoforms is associated with hypoxic tumours and clinically linked with malignant progression, treatment ...
Gieling, Roben, Williams, Kaye J.
core   +2 more sources

The structure and function of the fungal V-ATPase [PDF]

Journal of Experimental Biology, 1992
ABSTRACT The fungal vacuole is a prominent organelle that functions as a storage site for amino acids, Ca2+, storage carbohydrates, inorganic phosphate and numerous hydrolases (Fig. 1) (Klionsky et al. 1990). A hallmark of fungal vacuoles is that they are acidic compartments involved in the turnover of cellular macromolecules.
openaire   +3 more sources