Results 41 to 50 of about 7,391,818 (293)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The fatigue behavior of V-notches in presence of residual stresses: recent developments and future outcomes [PDF]
Fracture and Structural Integrity, 2017 Residual stresses, arising from welding processes or nonhomogeneous plastic deformations, broadly influence the high cycle fatigue behavior of mechanical components. The presence of V-notches leads to singular residual stresses ahead of the notch tip and
P. Ferro +4 more
doaj +3 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Skinless V-Notched Fillet Yields of Tilapia (Oreochromis)
International Journal of Recirculating Aquaculture, 2004 White hybrid tilapia (Oreochromis) produced in an experiment that determined the effects of various management practices on growth rate and feed conversion ratios were weighed, measured, and filleted at the conclusion of the growth trials. Regression analyses produced two models to predict fillet yields-one model that used the fish weight and length ...
Kirkup, S. P. +2 more
openaire +2 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
, 2016 The electronic transport properties of zigzag nanoribbons (ZGNRs) with V-shaped notches on the edges have been investigated by a first-principles method. It is found that for ZGNRs with medium and large-sized V-shaped notches, an obvious threshold of the
Zhao, Jianhua +5 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Use of J-integral to predict static failures in sharp V-notches and rounded U-notches
, 2008 In the present paper, the physical meaning of JV (namely, the classic J-integral applied to either sharp V-notch) is discussed. Consider a Cartesian reference frame having the x-axis parallel to the notch bisector, each mode of JV, for a given circular ...
LIVIERI, Paolo
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source