Results 51 to 60 of about 7,391,818 (293)

V-notch tip subjected to in-plane mixed mode loading: overview of recent results and possible future outcomes [PDF]

Fracture and Structural Integrity, 2017
The fictitious notch rounding concept is applied for the first time to V-notches with root hole subjected to in-plane mixed mode loading. Outof- bisector crack propagation is taken into account.
F. Berto
doaj   +2 more sources

Numerical Estimation of Notch Stress Intensity Factors of Sharp V-Notches

MATEC Web of Conferences, 2018
In the present work a simple and efficient least squares method is implemented for accurate estimation of notch stress intensity factors (NSIFs) of sharp V-notches.
Karim Hussain Mirzaul, Murthy K.S.R.K.
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Non-localized creep assessment of V-notched components: a review

Procedia Structural Integrity, 2017
Abstract: Geometrical discontinues such as notches need to be carefully analysed by engineers because of the stress concentration generated by them. Notches become even more important when the component is subjected, in service, to very severe conditions, such as the high temperature fatigue and imposed visco-plastic behaviour such as creep. The aim
Gallo, P., Berto, F., Razavi, S. M. J., Ayatollahi, M. R.   +4 more
openaire   +4 more sources

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Influence Rule of Annular Notch Geometric Parameter on the Tubing Surface: A Case Study

Metals, 2022
In regards to the problem of tubing precision separation, the high-efficiency precision separation method for tubing under eccentric wheel high-speed rotational bending fatigue loading is proposed, which aims to promote the initiation of fatigue cracks ...
Renfeng Zhao, Weicheng Gao, Dongya Zhang, Xudong Xiao, Yanwei Liu, Runze Pan, Hongwei Fan   +6 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

A Brief Review of Some Local Approaches for the Failure Assessment of Brittle and Quasi-Brittle Materials

Advances in Materials Science and Engineering, 2014
Brittle failure of components weakened by cracks and notches is a topic of active and continuous research. It is a key topic for all researchers who face the problem of fracture of materials under different loading conditions and deals with a large ...
F. Berto
doaj   +1 more source

An approximate, analytical approach to the `HRR'-solution for sharp V-notches [PDF]

International Journal of Fracture, 2002
The well-known so-called `HRR-solution' (Hutchinson, 1968 and Rice and Rosengren, 1968) considers the elasto-plastic stress field in a power-law strain hardening material near a sharp crack. It provides a closed form explicit expression for the stress singularity as a function of the power-law exponent `n' of the material, but the stress angular ...
Filippi S, Ciavarella M, Lazzarin P
openaire   +3 more sources

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source