AntibioticsBeta-lactam antibiotics have been a major climacteric in medicine for being the first bactericidal compound available for clinical use. They have continually been prescribed since their development in the 1940s, and their application has saved an ...
Trae Hillyer, Woo Shik Shin
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Aminoglycosides enhance meropenem/vaborbactam activity against KPC-producing <i>Klebsiella pneumoniae</i> in the hollow fiber infection model. [PDF]
Antimicrob Agents ChemotherSingh N +13 more
europepmc +2 more sources
The European Medicines Agency Approved the New Antibacterial Drugs – Response to the 2017 Who Report on the Global Problem of Multi-Drug Resistance [PDF]
Postępy Mikrobiologii, 2021 The growing problem of antimicrobial resistance has been classified by the World Health Organization (WHO) as one of the top ten threats to mankind. In a special report published in 2017, the WHO presented a list of microorganisms for which the search ...
Krajewska Joanna, Laudy Agnieszka Ewa
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PLoS ONE, 2021 Antimicrobial resistance (AMR) mediated by β-lactamases is the major and leading cause of resistance to penicillins and cephalosporins among Gram-negative bacteria.
Vijay Kumar +5 more
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Complete genome sequences of KPC-producing <i>Klebsiella pneumoniae</i> isolates pre- and post-development of meropenem/vaborbactam resistance. [PDF]
Microbiol Resour AnnouncOzer EA +5 more
europepmc +2 more sources
Biochemical Activity of Vaborbactam [PDF]
Antimicrobial Agents and Chemotherapy, 2020 The most common mechanism of resistance to β-lactams antibiotics in Gram-negative bacteria is production of β-lactamase enzymes capable of cleaving the β-lactam ring. Inhibition of β-lactamase activity with small-molecule drugs is a proven strategy to restore the potency of many β-lactam antibiotics.
Tsivkovski, Ruslan, Lomovskaya, Olga
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Microbiology Spectrum, 2023 Carbapenems are a common first-line therapy for serious Gram-negative infections, but carbapenem-resistant Enterobacterales (CRE) isolates have become an urgent health concern. Klebsiella pneumoniae serine carbapenemases (KPCs) now have been disseminated
Dee Shortridge +2 more
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Ultra-performance liquid chromatography-tandem mass spectrometric method for quantitation of the recently Food and Drug Administration approved combination of vaborbactam and meropenem in human plasma [PDF]
Royal Society Open Science, 2020 A parenteral medical combination containing vaborbactam and meropenem is used mainly to treat complicated urinary tract infections. A novel ultra-performance liquid chromatography tandem mass spectrometric method was developed for the sensitive ...
Ahmed K. Kammoun +3 more
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Mutation of kvrA Causes OmpK35 and OmpK36 Porin Downregulation and Reduced Meropenem-Vaborbactam Susceptibility in KPC-Producing Klebsiella pneumoniae [PDF]
, 2020 Meropenem/vaborbactam resistance in Klebsiella pneumoniae is associated with loss of function mutations in the OmpK35 and OmpK36 porins. Here we identify two previously unknown loss of function mutations that confer cefuroxime resistance in K. pneumoniae.
Punyawee Dulyayangkul +3 more
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, 2020 Serine β-lactamases are dominant causes of β-lactam resistance in Klebsiella pneumoniae isolates.
Punyawee Dulyayangkul +3 more
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