Results 1 to 10 of about 98,443 (105)

Intracellular Degradation of Helicobacter pylori VacA Toxin as a Determinant of Gastric Epithelial Cell Viability

Infection and Immunity, 2019
Helicobacter pylori VacA is a secreted pore-forming toxin that induces cell vacuolation in vitro and contributes to the pathogenesis of gastric cancer and peptic ulcer disease.
Anne Kenworthy, Ken Lau, Timothy Cover   +2 more
exaly   +2 more sources

Study of vacuolating cytotoxin A (vacA) genotypes of ulcerogenic and non-ulcerogenic strains of Helicobacter pylori and its association with gastric disease

Saudi Journal of Biological Sciences, 2023
Globally, Helicobacter pylori (H. pylori), a stomach pathogen, is present in around 50 % of the population. This bacterial infection produces persistent inflammation, which significantly raises the risk of duodenal, gastric ulcer, and stomach cancer. The
Mushtak T. S. Al-Ouqaili, R. A. Hussein, Y. Majeed, Farah Al-Marzooq   +3 more
semanticscholar   +1 more source

Treatment with Helicobacter pylori-derived VacA attenuates allergic airway disease

Frontiers in Immunology, 2023
Background Asthma is an incurable heterogeneous disease with variations in clinical and underlying immunological phenotype. New approaches could help to support existing therapy concepts.
S. Reuter, J. Raspe, Hendrik Uebner, Alexandros Contoyannis, E. Pastille, A. Westendorf, Georgia C. Caso, T. Cover, A. Müller, C. Taube   +9 more
semanticscholar   +1 more source

There Are No Insurmountable Barriers: Passage of the Helicobacter pylori VacA Toxin from Bacterial Cytoplasm to Eukaryotic Cell Organelle

Membranes, 2023
The Gram-negative bacterium Helicobacter pylori is a very successful pathogen, one of the most commonly identified causes of bacterial infections in humans worldwide. H.
M. Jarzab, J. Skórko-Glonek
semanticscholar   +1 more source

Host cell sensing and restoration of mitochondrial function and metabolism within Helicobacter pylori VacA intoxicated cells

mBio, 2023
Helicobacter pylori vacuolating cytotoxin A (VacA) is an intracellular-acting protein exotoxin that induces mitochondrial dysfunction and energy depletion within host cells. Although exposure to VacA results in mitochondrial dysfunction, one recent study
A. Seeger, F. Zaidi, S. Alhayek, Rachel M. Jones, Huzaifa Zohair, R. Holland, Ik-Jung Kim, Steven R. Blanke   +7 more
semanticscholar   +1 more source

Structural analysis of membrane-associated forms of Helicobacter pylori VacA toxin

Journal of Molecular Biology, 2023
Helicobacter pylori colonizes the stomach in about half of the human population, leading to an increased risk of peptic ulcer disease and gastric cancer. H. pylori secretes an 88 kDa VacA toxin that contributes to pathogenesis.
Sarah M. Connolly, A. Erwin, Megan Sabb, Jessica L. Hanks, Louise Chang, Rachel M. Torrez, Georgia C. Caso, A. Campbell, S. Mosalaganti, T. Cover, M. Ohi   +10 more
semanticscholar   +1 more source

VACA: Designing Variational Graph Autoencoders for Causal Queries

AAAI Conference on Artificial Intelligence, 2022
In this paper, we introduce VACA, a novel class of variational graph autoencoders for causal inference in the absence of hidden confounders, when only observational data and the causal graph are available.
Pablo Sánchez-Martín, Miriam Rateike, Isabel Valera   +2 more
semanticscholar   +1 more source

Electrochemical Immunosensor for Detection of H. pylori Secretory Protein VacA on g-C3N4/ZnO Nanocomposite-Modified Au Electrode

ACS Omega, 2022
A g-C3N4/ZnO (graphitic carbon nitride/zinc oxide) nanocomposite-decorated gold electrode was employed to design an antigen–antibody-based electrochemical biosensor to detect Helicobacter pylori specific toxin, vacuolating cytotoxin A (VacA). The thermal
K. Saxena, Arun Kumar, N. Chauhan, M. Khanuja, B. Malhotra, U. Jain   +5 more
semanticscholar   +1 more source

Clinical relevance of the cagA and vacA s1m1 status and antibiotic resistance in Helicobacter pylori: a systematic review and meta-analysis

BMC Infectious Diseases, 2022
Background The role of Helicobacter pylori ( H. pylori ) virulence factors of such as vacA s1m1 and cagA in designating clinical outcomes and eradication rate has been deeply challenged in the last decade.
M. Karbalaei, Amin Talebi Bezmin Abadi, M. Keikha   +2 more
semanticscholar   +1 more source

H. pylori Infection and Virulence Factors cagA and vacA (s and m Regions) in Gastric Adenocarcinoma from Pará State, Brazil

Pathogens, 2022
H. pylori shows a great variability in genes associated with virulence, which may influence properties related to gastric adenocarcinoma initiation and progression. Among them, cagA and vacA show a strong positive association with the disease. Therefore,
Igor Brasil-Costa, Cintya de Oliveira Souza, L. C. R. Monteiro, M. L. S. Santos, E. D. de Oliveira, R. Burbano   +5 more
semanticscholar   +1 more source