Results 11 to 20 of about 98,443 (105)

Outer Membrane Vesicle Production by Helicobacter pylori Represents an Approach for the Delivery of Virulence Factors CagA, VacA and UreA into Human Gastric Adenocarcinoma (AGS) Cells

International Journal of Molecular Sciences, 2021
Helicobacter pylori infection is the etiology of several gastric-related diseases including gastric cancer. Cytotoxin associated gene A (CagA), vacuolating cytotoxin A (VacA) and α-subunit of urease (UreA) are three major virulence factors of H.
Yongyu Chew, Hsin‐Yu Chung, Po-Yi Lin, Deng-Chyang Wu, Shau-ku Huang, M. Kao   +5 more
semanticscholar   +1 more source

Genotyping of Helicobacter pylori Virulence Genes cagA and vacA: Regional and National Study

International Journal of Microbiology, 2021
Helicobacter pylori (H. pylori) plays a crucial role in the pathogenesis of gastritis, peptic ulcer, and gastric cancer. The presence of pathogenicity islands (PAI) genes contributes to the pathogenesis of many gastrointestinal disorders.
Rania M. Kishk, N. Soliman, Maha M Anani, N. Nemr, A. Salem, Fawzy Attia, A. Allithy, M. Fouad   +7 more
semanticscholar   +1 more source

Profile of Helicobacter pylori cagA &vacA genotypes and its association with the spectrum of gastroduodenal disease.

Indian Journal of Medical Microbiology, 2021
PURPOSE Globally, H. pylori virulence factors cagA and vacA genotypes and its variation is leading to the austere form of the gastroduodenal disease. Our objectives were to detect H. pylori in dyspeptic patients from biopsy samples with the validation of
V. Shetty, Ramachandra Lingadakai, Ganesh C. Pai, M. Ballal   +3 more
semanticscholar   +1 more source

New genotypes of Helicobacter Pylori VacA d-region identified from global strains

BMC Molecular and Cell Biology, 2021
Background Pathogenesis of Helicobacter Pylori (HP) vacuolating toxin A (vacA) depends on polymorphic diversity within the signal (s), middle (m), intermediate (i), deletion (d) and c-regions. These regions show distinct allelic diversity.
Djaleel Muhammad Soyfoo, Yussriya Hanaa Doomah, Dong Xu, Chao Zhang, Huaiming Sang, Yan-Yan Liu, Guo-Xin Zhang, Jian-Xia Jiang, Shun-Fu Xu   +8 more
semanticscholar   +1 more source

Functional Properties of Oligomeric and Monomeric Forms of Helicobacter pylori VacA Toxin

Infection and Immunity, 2021
Helicobacter pylori VacA is a secreted toxin that assembles into water-soluble oligomeric structures and forms anion-selective membrane channels. Acidification of purified VacA enhances its activity in cell culture assays.
Georgia C. Caso, M. S. McClain, A. Erwin, Mandy D. Truelock, A. Campbell, Catherine S. Leasure, Marcus B. M. Nagel, K. Schey, D. Lacy, M. Ohi, T. Cover   +10 more
semanticscholar   +1 more source

Autophagy induced by H. pylori VacA regulated the survival mechanism of the SGC7901 human gastric cancer cell line

Genes & Genomics, 2021
Vacuolating cytotoxin (VacA) is an important virulence factor of Helicobacter pylori (H. pylori). It was previously believed that VacA can trigger the cascade of apoptosis on mitochondria to lead to cell apoptosis.
Juan Luo, Lu Bai, Jun Tao, Yu Wen, Mingke Li, Yun-Zhen Zhu, Su-Feng Luo, Guangyu Pu, Lan-Qing Ma   +8 more
semanticscholar   +1 more source

Geographic distribution of the cagA, vacA, iceA, oipA and dupA genes of Helicobacter pylori strains isolated in China

Gut Pathogens, 2020
Background There are geographic variations in the genotypes of Helicobacter pylori ( H. pylori ) cagA , vacA , iceA , oipA and dupA . The aim of the study was to investigate the distribution of these genotypes among H. pylori strains from five regions of
Zhi-Jing Xue, Hong Yang, D.-J. Su, Xiang-Feng Song, Xingqun Deng, Chang-Hong Yu, Chun-hua Sun, Li-Hua He, Yuanhai You, Ya-Nan Gong, Dong-Jie Fan, Lu Sun, Xiu-Rui Han, Ru-Yue Fan, Kang-Le Zhai, Ya-Ming Yang, Mao-Jun Zhang, Xiao-Mei Yan, J. Qian, Jian-Zhong Zhang   +19 more
semanticscholar   +1 more source

VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1

Nature Microbiology, 2019
Helicobacter pylori infection is a proven carcinogen for gastric cancer. Its virulence factor vacuolating cytotoxin A (VacA) promotes more severe disease and gastric colonization.
M. Capurro, Laura K. Greenfield, A. Prashar, S. Xia, Majd Abdullah, Harikesh S. Wong, X. Zhong, N. Bertaux‐Skeirik, J. Chakrabarti, I. Siddiqui, C. O’Brien, Xian-Ping Dong, Lisa A. Robinson, Richard M. Peek, D. Philpott, Y. Zavros, M. Helmrath, N. Jones   +17 more
semanticscholar   +1 more source

A vaca louca

, 2011
Ensino Médio::BiologiaÁudio produzido a partir do acervo radiofônico da Rádio UFMG Educativa - Programa Papo de Vaca.
Mateus, Alfredo Luís
core   +2 more sources

Ekspresja kisspeptyny oraz receptora GPR54 w tkance raka endometrium

Ekspresja kisspeptyny oraz receptora GPR54 w tkance raka endometrium
Kisspeptin (KISS) is a natural peptide-discovered in 1996 as a factor inhibiting the ability to metastasize in malignant melanoma. This protein plays also a regulatory role in the process of puberty, the menstrual cycle, spermatogenesis, implantation and

semanticscholar   +1 more source