Results 81 to 90 of about 3,236 (244)

Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic Peptides

Advanced Science, EarlyView.
This study systematically investigates how positional and subtle changes, such as substituents on the phenyl ring attached to short amphipathic peptides, influence their self‐assembly, fibril morphology, and immunogenic responses. ABSTRACT Self‐assembled peptide‐based biomaterials provide versatile platforms for biomedical uses, featuring customizable ...
Anirban Das, Ushasi Pramanik, Elise M. Brown, Chih‐Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P. Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E. Jackrel, Mark A. White, Jai S. Rudra   +13 more
wiley   +1 more source

Molecular characterization of chicken anemia virus and evaluation of maternally derived antibodies defense against commercially available vaccines

Beni-Suef University Journal of Basic and Applied Sciences
Background Chicken infectious anemia is a young chicken’s infection caused by a single-strand DNA gyrovirus and marked by aplastic anemia, lymphoid organs atrophy, and immunosuppression, causing severe financial losses to the poultry production.
Amal R. Abdel Aziz, Kh. M. Elbayoumi, Sanaa S. A. Awad, Samah M. Mosad, Kamel I. Abou El-Azm   +4 more
doaj   +1 more source

The early use of yellow fever virus strain 17D for vaccine production in Brazil - a review

Memorias do Instituto Oswaldo Cruz, 2001
The use of yellow fever (YF) virus 17D strain for vaccine production adapted in Brazil since its introduction in 1937 was reviewed. This was possible due to the availability of official records of vaccine production.
Paulo Roberto Post, Ricardo de Carvalho, Marcos da Silva Freire, Ricardo Galler   +3 more
doaj   +1 more source

[Evolution of vaccine poliovirus strains].

Voprosy virusologii, 2008
The paper considers different aspects of the molecular evolution of poliovirus vaccine strains: mutational and recombinant variability; mechanisms of fixation of occurring genetic changes. Matters concerning the policy of vaccination of the population against poliomyelitis are covered.
M L, Iakovenko, E A, Korotkova
openaire   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy

Advanced Science, EarlyView.
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou   +24 more
wiley   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

STUDYING DEVELOPMENT OF POST-VACCINAL CELLULAR IMMUNITY AGAINST BRUCELLOSIS BY MEANS OF LYMPHOCYTE IN VITRO TESTS USING AN EXPERIMENTAL ANTIGENIC COMPLEX

Медицинская иммунология, 2019
Introduction: regulatory framework and methodological approaches to evaluation of immunological effects of vaccination against brucellosis are not established, and the degree of immunological post-vaccinal rearrangement is not yet developed.
Dmitry Grigorievich Ponomarenko, Kostyuchenko Marina Vladimirovna, Rakitina Ekaterina Lvovna, Logvinenko Olga Vasilievna, Kurcheva Svetlana Aleksandrovna, Berdnikova Tatiana Vasilievna, Rusanova Diana Vladimirovna, Kulichenko Alexander Nikolaevich   +7 more
doaj  

Live vaccine strain recommendations for the human influenza vaccine

, 2020
Up to 5 million annual influenza infections cause substantial morbidity and mortality in seasonal epidemics around the globe. Human influenza A viruses undergo constant genetic and antigenic drift allowing recurrent infections in the human population. To ensure continued protection against influenza infections, the viral strains used for the production
Klingen, Thorsten, Reimering, Susanne, McHardy, Alice C.   +2 more
openaire   +1 more source