Results 1 to 10 of about 801,473 (190)

RIG-I Recognizes the 5′ Region of Dengue and Zika Virus Genomes

Cell Reports, 2018
Summary: The flavivirus genus comprises major human pathogens, such as Dengue (DENV) and Zika (ZIKV) viruses. RIG-I and MDA5 are key cytoplasmic pathogen recognition receptors that are implicated in detecting viral RNAs.
Maxime Chazal, Guillaume Beauclair, Ségolène Gracias, Valérie Najburg, Etienne Simon-Lorière, Frédéric Tangy, Anastassia V. Komarova, Nolwenn Jouvenet   +7 more
doaj   +1 more source

Modeling the Influence of Environment and Intervention on Cholera in Haiti [PDF]

, 2014
We propose a simple model with two infective classes in order to model the cholera epidemic in Haiti. We include the impact of environmental events (rainfall, temperature and tidal range) on the epidemic in the Artibonite and Ouest regions by introducing
Freitag, Caroline, Roudenko, Svetlana, Tennenbaum, Stephen   +2 more
core   +4 more sources

A safe and potentiated multi-type HPV L2-E7 nanoparticle vaccine with combined prophylactic and therapeutic activity

npj Vaccines
Persistent infection with high-risk human papillomavirus (HPV) is widely recognized as the primary cause of cervical and other malignant cancers. There are six licensed prophylactic vaccines available against HPV, but none of them shows any significant ...
Xueer Zhao, Yueru Zhang, Oscar Trejo-Cerro, Ecem Kaplan, Zhe Li, Femke Albertsboer, Neyla El Hammiri, Filipe Colaço Mariz, Lawrence Banks, Simone Ottonello, Martin Müller   +10 more
doaj   +1 more source

Cost-effectiveness of a potential Zika vaccine candidate: a case study for Colombia [PDF]

, 2018
Background: A number of Zika vaccine platforms are currently being investigated, some of which have entered clinical trials. We sought to evaluate the cost-effectiveness of a potential Zika vaccine candidate under the WHO Vaccine Target Product Profile ...
Moghadas, Seyed, Shoukat, Affan, Vilches, Thomas   +2 more
core   +2 more sources

Advances on two serological assays for human papillomavirus provide insights on the reactivity of antibodies against a cross-neutralization epitope of the minor capsid protein L2

Frontiers in Immunology, 2023
IntroductionA second generation of prophylactic human papillomavirus (HPV) vaccines based on the minor capsid protein L2 has entered clinical trials as promising alternative to meet the gaps left out by the current vaccines concerning type-restricted ...
Filipe Colaco Mariz, Kerstin Putzker, Peter Sehr, Martin Müller   +3 more
doaj   +1 more source

Spatial, temporal and spatio-temporal clusters of measles incidence at the county level in Guangxi, China during 2004–2014: flexibly shaped scan statistics

BMC Infectious Diseases, 2017
Background Outbreaks of measles re-emerged in Guangxi province during 2013–2014, where measles again became a major public health concern. A better understanding of the patterns of measles cases would help in identifying high-risk areas and periods for ...
Xianyan Tang, Alan Geater, Edward McNeil, Qiuyun Deng, Aihu Dong, Ge Zhong   +5 more
doaj   +1 more source

Broad Neutralization Responses Against Oncogenic Human Papillomaviruses Induced by a Minor Capsid L2 Polytope Genetically Incorporated Into Bacterial Ferritin Nanoparticles

Frontiers in Immunology, 2020
Cervical cancer remains a global health burden despite the introduction of highly effective vaccines for the prophylaxis of causative human papillomavirus infection (HPV).
Fan Yang, Filipe C. Mariz, Xueer Zhao, Gloria Spagnoli, Simone Ottonello, Martin Müller   +5 more
doaj   +1 more source

Influenza vaccination uptake among people aged over 85 years: an audit of primary care practice in the UK [PDF]

, 2014
Public health research and national guidelines have advocated for seasonal influenza vaccination in the elderly. General practice has established itself as an ideal setting for the safe administration and monitoring of vaccines.1 Due to waning immune
Arnott, ND, Fitchett, JR
core   +2 more sources

Systematic Literature Review of The Effects Of Clinical Mentoring On New Graduate Registered Nurses’ Clinical Performance, Job Satisfaction And Job Retention

Asia Pacific Journal of Health Management, 2021
Objective: The purpose of this systematic literature review is to appraise contemporary research literature examining the effects of mentoring on graduate registered nurses’ transition to practice objectively and systematically.
Jo-Anne Marie Vidal, Richard Olley
doaj   +1 more source

Vaccine Epidemiology and Decision-Making: A Bryant Student Focus [PDF]

, 2018
The Centers for Disease Control and Prevention estimate that influenza has resulted in between 9.2 and 35.6 million illnesses and between 12,000 and 56,000 deaths annually since 2010 (1).
Coburn, Hannah
core   +1 more source