Results 31 to 40 of about 837,399 (259)

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

Assessment of Mycobacterium tuberculosis dodecin scaffold as a multimerization platform on the immunogenicity of HPV L2 antigens

Scientific Reports
Human papillomavirus infection, the primary cause of cervical cancer (the fourth most common cancer in women), is preventable through prophylactic HPV vaccines. As an alternative to current HPV vaccines, all based on a cocktail of L1 virus-like particles
Ecem Kaplan, Filipe Colaco Mariz, Xueer Zhao, Michelle Nessling, Lara Veitl, Yueru Zhang, Heiko Weyd, Martin Müller   +7 more
doaj   +1 more source

Validating child vaccination status in a demographic surveillance system using data from a clinical cohort study: evidence from rural South Africa [PDF]

, 2011
<p><b>Background:</b> Childhood vaccination coverage can be estimated from a range of sources. This study aims to validate vaccination data from a longitudinal population-based demographic surveillance system (DSS) against data from a ...
Barnighausen, T., Ndirangu James, James Ndirangu, Marie-Louise Newell, Ndirangu, J., Bärnighausen Till, Bland Ruth, Bland, R., Ruth Bland, Till Bärnighausen, Newell Marie-Louise, Newell, M.-L.   +11 more
core   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Vaccination strategies to conserve the endangered African wild dog (Lycaon pictus) [PDF]

, 2011
Pathogens such as rabies virus and canine distemper virus present a significant risk to the long-term survival of some endangered African wild dog (Lycaon pictus) populations.
Haydon, Daniel T, Prager, K.C., Woodroffe, R., Cameron, Angus   +3 more
core   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A safe and potentiated multi-type HPV L2-E7 nanoparticle vaccine with combined prophylactic and therapeutic activity

npj Vaccines
Persistent infection with high-risk human papillomavirus (HPV) is widely recognized as the primary cause of cervical and other malignant cancers. There are six licensed prophylactic vaccines available against HPV, but none of them shows any significant ...
Xueer Zhao, Yueru Zhang, Oscar Trejo-Cerro, Ecem Kaplan, Zhe Li, Femke Albertsboer, Neyla El Hammiri, Filipe Colaço Mariz, Lawrence Banks, Simone Ottonello, Martin Müller   +10 more
doaj   +1 more source

Ascertainment of childhood vaccination histories in northern Malawi.

, 2008
OBJECTIVE: To assess factors related to recorded vaccine uptake, which may confound the evaluation of vaccine impact. METHODS: Analysis of documented vaccination histories of children under 5 years and demographic and socio-economic characteristics ...
Mwinuka, V, Mwagomba, D., Crampin, A.C., McGrath, N, J. Mwafilaso, A. Jahn, Karsulukuta, A., Khunga, A, P. E. M. Fine, Mkisi, RE, Branson, K, A. Katsulukuta, Floyd, S., A. C. Crampin, K. Branson, V. Mwinuka, Branson, K., Fine, P.E.M., Mwafilaso, J., McGrath, N., D. Mwagomba, Khunga, A., S. Floyd, Katsulukuta, A, A. Khunga, Mwafilaso, J, N. McGrath, Jahn, A, Jahn, A., Mwinuka, V., R. E. Mkisi, Crampin, AC, Mwagomba, D, Mkisi, R.E., Katsulukuta, A., Fine, PEM, Floyd, S   +36 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

RIG-I Recognizes the 5′ Region of Dengue and Zika Virus Genomes

Cell Reports, 2018
Summary: The flavivirus genus comprises major human pathogens, such as Dengue (DENV) and Zika (ZIKV) viruses. RIG-I and MDA5 are key cytoplasmic pathogen recognition receptors that are implicated in detecting viral RNAs.
Maxime Chazal, Guillaume Beauclair, Ségolène Gracias, Valérie Najburg, Etienne Simon-Lorière, Frédéric Tangy, Anastassia V. Komarova, Nolwenn Jouvenet   +7 more
doaj   +1 more source