Results 51 to 60 of about 1,093,262 (297)

Parenteral vaccination of mammalian livestock with Newcastle disease virus-based vector vaccines offers optimal efficacy and safety [PDF]

, 2011
Newcastle disease virus (NDV) is an avian virus that is being evaluated as a vaccine vector for the delivery of foreign genes in mammals. The use of NDV as a vaccine vector in these species offers two major advantages.
Antonis, A.F.G., Harmsen, M.M., Kortekaas, J.A., Moormann, R.J.M.   +3 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Comparison of antibody titres between intradermal and intramuscular rabies vaccination using inactivated vaccine in cattle in Bhutan : a thesis presented in the partial fulfilment of the requirements for the degree of Master of Veterinary Science at Massey University, Palmerston North, New Zealand [PDF]

, 2018
In developing countries, the cost of vaccination limits the use of prophylactic rabies vaccination, especially in cattle. Intradermal vaccination delivers antigen directly to an area with higher number of antigen-presenting cells.
Wangmo, Karma
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Advances on two serological assays for human papillomavirus provide insights on the reactivity of antibodies against a cross-neutralization epitope of the minor capsid protein L2

Frontiers in Immunology, 2023
IntroductionA second generation of prophylactic human papillomavirus (HPV) vaccines based on the minor capsid protein L2 has entered clinical trials as promising alternative to meet the gaps left out by the current vaccines concerning type-restricted ...
Filipe Colaco Mariz, Kerstin Putzker, Peter Sehr, Martin Müller   +3 more
doaj   +1 more source

Vaccines and Vaccination

, 2015
Livestock vaccines aim to increase livestock product and improve the health and welfare of livestock animals in a cost-efficient manner and prevent disease transmission. Successful livestock vaccines have been generated for pathogens including bacterial, viral, protozoan, and multicellular pathogens.
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

The importance of first-void urine for assessing HPV-specific antibodies: A comparison with midstream urine

Human Vaccines & Immunotherapeutics
Humoral immunity to HPV is typically assessed via serum, which reflects systemic immune responses. However, local sampling may offer a more accurate representation of immunity at the site of infection.
Anne Van Caesbroeck, Marijana Lipovac, Sofie Rennen, Laura Téblick   +3 more
doaj   +1 more source

Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis [PDF]

, 2019
Background More than 10 years have elapsed since human papillomavirus (HPV) vaccination was implemented. We did a systematic review and meta-analysis of the population-level impact of vaccinating girls and women against human ...
\uc9lodie, B\ue9nard, A Kahn, Jessica, A Machalek, Dorothy, A Smith, Megan, Ali, Hammad, Baldo, Vincenzo, Boily, MarcMarie\uadClaude, Brassard, Paul, Brisson,, Callander, Denton, Checchi, Marta, Cocchio, Silvia, Dalianis, Tina, Dehlendorff, Christian, Donovan, Basil, F Chow, Eric P, G Pollock, Kevin, Gr\ufcn, Nathalie, Harrison, Christopher, Herweijer, Eva, J Woestenberg, Petra, Jes\ufas Purri\uf1os\uadHermida, Mar\ueda, K Fairley, Christopher, K Kjaer, Susanne, Kavanagh, Kimberley, L Brotherton, Julia M, L Deeks, Shelley, Liu, Bette, M Garland, Suzanne, M Imburgia, Teresa, M Johnson, Anne, M Wheeler, Cosette, M\ue9lanie, Drolet, Markowitz, Lauri, Mesher, David, Munk, Christian, Niccolai, Linda, Norma, P\ue9rez, Nyg\ue5rd, Mari, Ogilvie, Gina, Oliphant, Jeannie, S\uf6derlund\uadStrand, Anna, Sonnenberg, Pam, Sparen, P\ue4r, Steben, Marc, T Hansen, Bo, Tanton, Clare, V Kliewer, Erich, W Flagg, Elaine, W Gargano, Julia, Yu., Bo Nancy   +50 more
core   +2 more sources