Results 121 to 130 of about 44,954 (187)

Advances in Cellular Immune Theranostic Approaches for Glioblastoma: Current Trends and Future Directions

Cancer Innovation, Volume 4, Issue 4, August 2025.
Glioblastoma (GBM) remains a highly malignant brain tumor with limited treatment efficacy, driving the need for innovative cellular immune theranostic strategies that integrate diagnostic and therapeutic approaches. Recent advances in cellular immunotherapy for GBM include chimeric antigen receptor (CAR)‐T/NK cells, macrophage‐based therapies ...
Ying Gong, Wanying Lin, Xuechun Fang, Ruyi Zhang, Min Luo, Haoran Wu, Shuai Chu, Chuangkun Li, Yiming Peng, Zhiyan Piao, Siping Wu, Junhao Li, ZongZhong He, Haixia Li, Hongxia Wang   +14 more
wiley   +1 more source

Immunodeficiency-associated Vaccine-Derived Poliovirus Type 3 in Infant, South Africa, 2011

Emerging Infectious Diseases, 2012
Patients with primary immunodeficiency are prone to persistently excrete Sabin-like virus after administration of live-attenuated oral polio vaccine and have an increased risk for vaccine-derived paralytic polio.
Nicksy Gumede, Vongani Muthambi, Barry D. Schoub   +2 more
doaj   +1 more source

Update on Vaccine-Derived Poliovirus Outbreaks — Worldwide, January 2018–June 2019 [PDF]

MMWR. Morbidity and Mortality Weekly Report, 2019
Certification of global eradication of indigenous wild poliovirus type 2 occurred in 2015 and of type 3 in 2019. Since the launch of the Global Polio Eradication Initiative (GPEI) in 1988 and broad use of live, attenuated oral poliovirus vaccine (OPV), the number of wild poliovirus cases has declined >99.99% (1).
Jorba, Jaume, Diop, Ousmane M., Iber, Jane, Henderson, Elizabeth, Zhao, Kun, Quddus, Arshad, Sutter, Roland, Vertefeuille, John F., Wenger, Jay, Wassilak, Steven G.F., Pallansch, Mark A., Burns, Cara C.   +11 more
openaire   +3 more sources

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, Volume 5, Issue 4, August 2025.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Are Circulating Type 2 Vaccine-derived Polioviruses (VDPVs) Genetically Distinguishable from Immunodeficiency-associated VDPVs?

Computational and Structural Biotechnology Journal, 2017
Public health response to vaccine-derived poliovirus (VDPV) that is transmitted from person to person (circulating VDPV [cVDPV]) differs significantly from response to virus that replicates in individuals with primary immunodeficiency (immunodeficiency ...
Kun Zhao, Jaume Jorba, Jing Shaw, Jane Iber, Qi Chen, Kelley Bullard, Olen M. Kew, Cara C. Burns   +7 more
doaj   +1 more source

Exploring the Role of Pattern Recognition Receptors as Immunostimulatory Molecules

Immunity, Inflammation and Disease, Volume 13, Issue 5, May 2025.
This mini‐review summarizes different classes of pattern recognition receptors (PRRs) and the role of their agonizts that have been identified and also outlines the role of PRR ligands as immunostimulatory molecules. Overall, the mini‐review has elaborated on the role of PRRs in the development of therapeutic vaccine adjuvants.
Meenal Sharma, Priyanka Wagh, Tanvi Shinde, Diptee Trimbake, Anuradha S. Tripathy   +4 more
wiley   +1 more source

Targeting WDPF domain of Hsp27 achieves a broad spectrum of antiviral

MedComm, Volume 6, Issue 3, March 2025.
Ser78 phosphorylation of Hsp27 plays an important role in Hsp27 nuclear translocation, which induces hnRNP A1 cytosol relocation and further enhances the IRES activity and viral replication mediated by EV‐A71 2Apro. Hsp27‐derived WDPF peptide competitively inhibited Hsp27 phosphorylation on serine 78 to block Hsp27/hnRNP A1 translocation and further ...
Mandi Wu, Wei Li, Houying Leung, Yiran Wang, Qianya Wan, Peiran Chen, Cien Chen, Yichen Li, Xi Yao, Ming‐Liang He   +9 more
wiley   +1 more source

The role of the gut microbiota in regulating responses to vaccination: current knowledge and future directions

The FEBS Journal, Volume 292, Issue 6, Page 1480-1499, March 2025.
Vaccination plays a crucial role in mediating protection against infectious diseases, but immune responses to vaccination are highly variable and frequently sub‐optimal in vulnerable populations. Here, we review the latest preclinical and clinical evidence demonstrating that the gut microbiota plays a significant role in regulating immune responses to ...
Charné Rossouw, Feargal J. Ryan, David J. Lynn   +2 more
wiley   +1 more source

Vaccine-Derived Poliovirus Infection among Patients with Primary Immunodeficiency and Effect of Patient Screening on Disease Outcomes, Iran

Emerging Infectious Diseases, 2019
Patients with immunodeficiency-associated vaccine-derived poliovirus (iVDPV) are potential poliovirus reservoirs in the posteradication era that might reintroduce polioviruses into the community.
Mohammadreza Shaghaghi, Shohreh Shahmahmoodi, Ali Nili, Hassan Abolhassani, Seyedeh Panid Madani, Ahmad Nejati, Maryam Yousefi, Yaghoob M. Kandelousi, Mona Irannejad, Shiva Shaghaghi, Seyed Mohsen Zahraei, Sussan Mahmoudi, Mohammad Mehdi Gouya, Reza Yazdani, Gholamreza Azizi, Nima Parvaneh, Asghar Aghamohammadi   +16 more
doaj   +1 more source

Case of Poliomyelitis Caused by Significantly Diverged Derivative of the Poliovirus Type 3 Vaccine Sabin Strain Circulating in the Orphanage

Viruses, 2020
Significantly divergent polioviruses (VDPV) derived from the oral poliovirus vaccine (OPV) from Sabin strains, like wild polioviruses, are capable of prolonged transmission and neuropathology. This is mainly shown for VDPV type 2.
Ekaterina A. Korotkova, Maria A. Prostova, Anatoly P. Gmyl, Liubov I. Kozlovskaya, Tatiana P. Eremeeva, Olga Y. Baikova, Alexandr Y. Krasota, Nadezhda S. Morozova, Olga E. Ivanova   +8 more
doaj   +1 more source