Results 131 to 140 of about 44,954 (187)

Insights Into Enterovirus D68 Immunology: Unraveling the Mysteries of Host‐Pathogen Interactions

Immunity, Inflammation and Disease, Volume 13, Issue 2, February 2025.
This review provides a comprehensive overview of the immunological responses to Enterovirus D68, offering valuable insights for researchers, clinicians, and public health professionals working towards effective prevention and control strategies. ABSTRACT Background Enterovirus D68 (EV‐D68) has emerged as a significant respiratory and neurological ...
Asif Naeem, Muhammad Bashir Bello, Mohammad Bosaeed   +2 more
wiley   +1 more source

Impediments to Progress Toward Polio Eradication During 2014–2024: Effectively Addressing the Current Challenges

Vaccines
When the Global Polio Eradication Initiative (GPEI) began in 1988, the year 2000 target was clearly ambitious. Nonetheless, among 20 countries with endemic wild poliovirus transmission in 2000, only Afghanistan, Nigeria and Pakistan remained endemic in ...
Steven G. F. Wassilak, Abdinoor Mohamed, John Paul Bigouette   +2 more
doaj   +1 more source

Viral Live‐Attenuated Vaccines (LAVs): Past and Future Directions

Advanced Science, Volume 12, Issue 3, January 20, 2025.
Live attenuated vaccines represent a delicate equilibrium between virulence and immunogenicity during adaptation. The process of animal adaptation involves artificial selection; therefore, adapted viruses exhibit decreased pathogenicity to their original hosts and increased pathogenicity to their adapted hosts.
Yan‐Dong Tang, Yuming Li, Xue‐Hui Cai, Xin Yin   +3 more
wiley   +1 more source

Two Cases of Vaccine-Derived Poliovirus Infection in an Oncology Ward

New England Journal of Medicine, 2016
The oral poliovirus vaccine strains can revert to virulent forms and establish chronic infection in persons with a weakened immune system. The authors describe such infection in two children and clearance of infection through immune recovery.
Sindy Böttcher, Anna Maria Eis-Hübinger, Axel Schubert   +2 more
openaire   +2 more sources

Metastatic brain tumors: from development to cutting‐edge treatment

MedComm, Volume 6, Issue 1, January 2025.
This abstract briefly reviews the diagnosis and treatment of brain metastases from lung cancer and breast cancer, the progress of artificial intelligence and multiomics. Importantly, we focus on the pathogenesis of brain metastases and the tumor microenvironment to seek treatment strategies.
Guilong Tanzhu, Liu Chen, Jiaoyang Ning, Wenxiang Xue, Ce Wang, Gang Xiao, Jie Yang, Rongrong Zhou   +7 more
wiley   +1 more source

Immunogenicity and safety evaluation of bivalent types 1 and 3 oral poliovirus vaccine by comparing different poliomyelitis vaccination schedules in China: A randomized controlled non-inferiority clinical trial

Human Vaccines & Immunotherapeutics, 2017
Background: The type 2 component of the oral poliovirus vaccine is targeted for global withdrawal through a switch from the trivalent oral poliovirus vaccine (tOPV) to a bivalent oral poliovirus vaccine (bOPV). The switch is intended to prevent paralytic
Jingjun Qiu, Yunkai Yang, Lirong Huang, Ling Wang, Zhiwei Jiang, Jian Gong, Wei Wang, Hongyan Wang, Shaohong Guo, Chanjuan Li, Shuyuan Wei, Zhaojun Mo, Jielai Xia   +12 more
doaj   +1 more source

Twenty-Eight Years of Poliovirus Replication in an Immunodeficient Individual: Impact on the Global Polio Eradication Initiative.

PLoS Pathogens, 2015
There are currently huge efforts by the World Health Organization and partners to complete global polio eradication. With the significant decline in poliomyelitis cases due to wild poliovirus in recent years, rare cases related to the use of live ...
Glynis Dunn, Dimitra Klapsa, Thomas Wilton, Lindsay Stone, Philip D Minor, Javier Martin   +5 more
doaj   +1 more source

Environmental Surveillance of Polioviruses in Armenia, Colombia before Trivalent Oral Polio Vaccine Cessation

Viruses, 2019
Although acute flaccid paralysis (AFP) surveillance is the “gold standard” for detecting cases of polio, environmental surveillance can provide supplementary information in the absence of paralytic poliomyelitis cases.
María Mercedes González, Magile C. Fonseca, Carlos Andrés Rodríguez, Alejandra María Giraldo, José Joaquín Vila, Jhon Carlos Castaño, Leonardo Padilla, Luis Sarmiento   +7 more
doaj   +1 more source

Notes from the Field: Readiness for Use of Type 2 Novel Oral Poliovirus Vaccine in Response to a Type 2 Circulating Vaccine-Derived Poliovirus Outbreak — Tajikistan, 2020–2021 [PDF]

, 2022
Patrick O’Connor, Shahin Huseynov, Carrie Nielsen, Faizali Saidzoda, Eugene Saxentoff, Umeda Sadykova, Patricia Kormoss   +6 more
openalex   +1 more source

Comparative Randomized Study of Tolerability, Reactogenicity, Immunogenicity and Safety of the Vaccine «BiVac Polio» (Oral Poliovirus Vaccine Type 1,3)

Эпидемиология и вакцинопрофилактика, 2017
Through the use of trivalent oral poliovirus vaccine made from Sabin strains of types 1, 2, 3 (tOPV), outstanding success of Global polio eradication program has been achieved. Since 1999, wild polio virus type 2 does not circulate in the world.
Yu. H. Khapchaev, O. E. Ivanova, M. F. Vorovitch, V. V. Romanenko, A. E. Makarov, S. G. Drozdov, A. A. Ishmukhametov   +6 more
doaj   +1 more source