Results 111 to 120 of about 32,135 (260)

Glutathione‐Responsive Acyl‐Modifications for Targeted RNA Decaging and Prolonged Protein Synthesis

Angewandte Chemie, EarlyView.
The self‐immolation of disulfide‐based mRNA modifications in response to endogenous glutathione (GSH) promotes a gradual release of translatable mRNA within the cell, leading to improved nuclease resistance, tunable release properties, and a significant increase (up to 600%) of target protein production over time. This strategy offers an exciting proof
Mary E. Flood, Sathishkumar Kurusamy, Mark Berney, C. Mark Smales, Elizabeth M. Topp, Joanna F. McGouran, Steven Ferguson   +6 more
wiley   +2 more sources

Engraftment of sheep splenic lymphocytes into NBSGW mice and application in Brucella infection

Animal Models and Experimental Medicine, EarlyView.
A sheep splenocyte‐reconstituted mouse model (Sh‐Spl mice) was established via intravenous injection of sheep splenic lymphocytes into immunodeficient mice to evaluate Brucella infection. Abstract Background The development of immune reconstituted xenograft mouse models has addressed the limitations imposed by interspecies immunological differences in ...
Xiaowei Wang, Shicheng Wan, Yanmin Guo, Hongyu Han, Fei Luo, Dongmei Jiang, Xiaorong Yang, Quanhai Pang, Haisheng Yu, Jinlian Hua   +9 more
wiley   +1 more source

Establishment and characterization of mouse lymph node fibrosis models

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Schematic illustration of four strategies for establishing mouse lymph node (LN) fibrosis models. The study further compares their fibrotic remodeling patterns and immune alterations. Abstract Background Lymph node (LN) fibrosis occurs in a variety of pathological conditions, including HIV infection, obesity, cancer, and
Yaru Niu, Xu Guan, Jian Ma, Xin Zhang, Yihang Shi, Jinzhu Zhang, Leiqiong Gao, Wei Chen, Xishan Wang   +8 more
wiley   +1 more source

Advances in vaccine-preventable diseases

International Journal of Infectious Diseases
Introduction: Vaccine-preventable diseases (VPDs) remain a significant cause of morbidity and mortality in children. Methods: Recent advances in VPDs were reviewed. Results: A modelling study showed that vaccinations accounted for 40% of the reduction of infant mortality during 1974-2024. Measles vaccines accounted for most of the averted mortality the
openaire   +2 more sources

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source

Safety and Feasibility of Magnetic Separation‐Based Blood Purification

Advanced NanoBiomed Research, EarlyView.
We present the preclinical biological safety and translational feasibility of a magnetic nanoparticle‐based extracorporeal blood purification platform for removal of disease‐causing blood factors. ISO 10993‐compliant studies and exaggerated worst‐case exposure models demonstrate efficient nanoparticle extraction (≥99.9%), favorable biocompatibility ...
Carlos A. Mora, Laurine Rijsbergen, Jan Waskowski, Gaelle Clermont, Florian Dingreville, Chandrashekara Vishwanath, Rajesh Karunanithi, Alexander Gogos, Jean‐Claude Metzger, Manuel Baumgartner, Joerg C. Schefold, Inge K. Herrmann   +11 more
wiley   +1 more source

Risk of reintroduction of vaccine-preventable diseases in the state of São Paulo, Brazil. [PDF]

Rev Saude Publica
Santana JES, Nerger MLBR, Agostini TL, Santos JRDC, Lachtim SAF, Silva CSO, Silva TPRD, Matozinhos FP.   +7 more
europepmc   +1 more source

Risk mitigation for vaccine-preventable diseases in the dental clinic. [PDF]

Germs, 2023
Săndulescu O, Săndulescu M.
europepmc   +1 more source

Letter to the Editor

Canadian Journal of Infectious Diseases and Medical Microbiology, 2013
Michelle Shuel, Raymond SW Tsang
doaj   +1 more source

Global burden and time trends of vaccine-preventable diseases in children and adolescents. [PDF]

Ital J Pediatr
Jin X, Wang R, Tu S, Yuan C, Ge F, Liu Y, Wang S, Ma Y, Sun G.   +8 more
europepmc   +1 more source