Results 51 to 60 of about 32,135 (260)

Chiral Microneedle Arrays With Terahertz Chiroptical Activity With Chiral‐Plasmon‐Chiral‐Phonon Resonance

Advanced Materials, EarlyView.
ABSTRACT Microneedle arrays (MNAs) is a rapidly emerging technology with broad biomedical applications in drug delivery and biosensing. With sub‐millimeter dimensions and periodicity, MNAs possess geometries nearly ideal for biomedical devices operating within the terahertz (THz) spectral window.
Sang Hyun Lee, Hong Ju Jung, John Kim, Bum Chul Park, Caio V. C. R. da Silva, André F. de Moura, Nicholas A. Kotov   +6 more
wiley   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Vaccine-Preventable Disease Control in the WHO African Region After the COVID-19 Public Health Emergency of International Concern: Implications for Recovery, Resilience, and System Transformation

Vaccines
Background: The end of the COVID-19 public health emergency of international concern (PHEIC) in May 2023 marked a transition from disruption to recovery and rebuilding of health systems.
Charles S. Wiysonge, Abdu A. Adamu, Ado M. Bwaka, Constance N. Wiysonge, Johnson M. Ticha, Reggis Katsande, Andre A. Bita Fouda, Nosheen Safdar, Aschalew Teka Bekele, Chinwe Iwu-Jaja, Blaise Bathondoli, Sidy Ndiaye, Adidja Amani, Maurice Demanou, Samafilan Ainan, Miluka P. Gunaratna, Awa Diop, Yue Han, Anfumbom Kfutwah, Renias Mukaro, Reena H. Doshi, Charles O. Lukoya, Kwasi Nyarko, Jason M. Mwenda, Balcha G. Masresha   +24 more
doaj   +1 more source

Use of Multiplex Quantitative PCR To Evaluate the Impact of Pneumococcal Conjugate Vaccine on Nasopharyngeal Pneumococcal Colonization in African Children

mSphere, 2017
Pneumococcal conjugate vaccine (PCV) immunization of children induces shifts in colonizing pneumococcal serotypes. This study evaluated the effect of infant vaccination with 7-valent PCV (PCV7) on vaccine serotype (VT) colonization and whether the ...
Courtney P. Olwagen, Peter V. Adrian, Marta C. Nunes, Michelle J. Groome, Mark F. Cotton, Avy Violari, Shabir A. Madhi   +6 more
doaj   +1 more source

Critical Spatial Clusters for Vaccine Preventable Diseases

, 2020
The standard public health intervention for controlling the spread of highly contagious diseases, such as measles, is to vaccinate a large fraction of the population. However, it has been shown that in some parts of the United States, even though the average vaccination rate is high, geographical clusters of undervaccinated populations are emerging ...
Jose Cadena, Achla Marathe, Anil Vullikanti   +2 more
openaire   +3 more sources

Microneedles Mediated Delivery of Nanodiamonds for Quantum Sensing of Free Radicals in Skin Tissue

Advanced Materials Technologies, EarlyView.
Fluorescent nanodiamonds are nanoscale sensors capable of monitoring cellular stress responses. However, to function effectively, they must be delivered into cells or tissues. Here, we demonstrate their application in the skin by developing a dissolvable microneedle platform that dissolves after skin insertion, enabling the delivery of nanodiamonds ...
Siyu Fan, Maria Carmona Lobita, Thea Vedelaar, Yue Zhang, Claudia Reyes‐San‐Martin, Tomás Bauleth‐Ramos, Gésinda Geertsema‐Doornbusch, Han Gao, Mohammad‐Ali Shahbazi, Hélder A. Santos, Romana Schirhagl   +10 more
wiley   +1 more source

The impact of adolescent pertussis immunization, 2004-2009: lessons from Australia

Bulletin of the World Health Organization, 2011
OBJECTIVE: To compare the impact of three strategies for delivering a booster dose of adult-formulated tetanus-diphtheria-pertussis (Tdap) vaccine to adolescents in Australia.
Helen E Quinn, Peter B McIntyre
doaj  

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

ProSiteHunter: A Unified Framework for Sequence‐Based Prediction of Protein‐Nucleic Acid and Protein‐Protein Binding Sites

Advanced Science, EarlyView.
This study proposed a unified sequence‐based framework for protein binding site prediction, which adopted a tri‐track semantic multi‐source feature fusion strategy to effectively capture diverse macromolecular interaction sites and further improved the accuracy of antibody‐antigen interaction prediction.
Dongliang Hou, Qihang Zhen, Zexin Lv, Xinyue Cui, Suhui Wang, Minghua Hou, Zhan Zhou, Xiaogen Zhou, Guijun Zhang   +8 more
wiley   +1 more source