Results 41 to 50 of about 2,114,452 (380)

SARS-CoV-2 mRNA Vaccine Design Enabled by Prototype Pathogen Preparedness

Nature, 2020
A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the coronavirus disease 2019 (COVID-19) global pandemic.
Kizzmekia S. Corbett, D. Edwards, S. Leist, O. Abiona, Seyhan Boyoglu-Barnum, Rebecca A. Gillespie, Sunny Himansu, A. Schäfer, Cynthia T Ziwawo, Anthony T. DiPiazza, K. Dinnon, Sayda M. Elbashir, C. Shaw, Angela Woods, Ethan J. Fritch, David R. Martinez, Kevin W. Bock, Mahnaz Minai, Bianca M. Nagata, Geoffrey B. Hutchinson, Kai Wu, C. Henry, Kapil Bahl, Dario Garcia-Dominguez, LingZhi Ma, Isabella Renzi, W. Kong, S. Schmidt, Lingshu Wang, Yi Zhang, Emily Phung, Lauren A. Chang, Rebecca J. Loomis, N. Altaras, Elisabeth Narayanan, Mihir Metkar, Vladimir Presnyak, Cuiping Liu, M. Louder, W. Shi, K. Leung, E. Yang, A. West, K. Gully, Laura J. Stevens, Nianshuang Wang, D. Wrapp, N. Doria-Rose, Guillaume B. E. Stewart-Jones, H. Bennett, Gabriela Alvarado, M. Nason, T. Ruckwardt, J. McLellan, M. Denison, J. Chappell, Ian N. Moore, Kaitlyn M. Morabito, J. Mascola, R. Baric, A. Carfi, B. Graham   +61 more
semanticscholar   +1 more source

Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant

New England Journal of Medicine, 2021
Background Assessment of the safety and efficacy of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different populations is essential, as is investigation of the efficacy of the vaccines against emerging SARS-CoV-2 ...
S. Madhi, V. Baillie, C. Cutland, M. Voysey, A. Koen, L. Fairlie, S. Padayachee, K. Dheda, S. Barnabas, Q. Bhorat, Carmen Briner, G. Kwatra, K. Ahmed, P. Aley, Sutika Bhikha, J. Bhiman, A. Bhorat, J. du Plessis, A. Esmail, M. Groenewald, E. Horne, Shi-Hsia Hwa, A. Jose, T. Lambe, M. Laubscher, M. Malahleha, Masebole Masenya, Mduduzi S. L. Masilela, Shakeel Mckenzie, Kgaogelo Molapo, A. Moultrie, S. Oelofse, Faeezah Patel, S. Pillay, S. Rhead, H. Rodel, Lindie Rossouw, Carol Taoushanis, H. Tegally, Asha Thombrayil, Samuel van Eck, C. K. Wibmer, N. Durham, E. Kelly, T. Villafana, S. Gilbert, A. Pollard, Tulio de Oliveira, P. Moore, A. Sigal, A. Izu   +50 more
semanticscholar   +1 more source

Development of an inactivated vaccine candidate for SARS-CoV-2

Science, 2020
Vaccine candidate tested in monkeys Global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent race to develop a vaccine. Gao et al.
Q. Gao, L. Bao, H. Mao, Lin Wang, K. Xu, Minnan Yang, Yajing Li, Ling Zhu, Nan Wang, Zhe Lv, Hong Gao, Xiaoqin Ge, B. Kan, Yalin Hu, Jiangning Liu, Fang Cai, D. Jiang, Yanhui Yin, C. Qin, Jing Li, X. Gong, X. Lou, W. Shi, Dongdong Wu, Hengming Zhang, Lang Zhu, Wei Deng, Yurong Li, Jinxing Lu, Changgui Li, Xiangxi Wang, W. Yin, Yanjun Zhang, Chuan Qin   +33 more
semanticscholar   +1 more source

Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial

Science, 2021
Description Antibody levels predict vaccine efficacy Symptomatic COVID-19 infection can be prevented by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.
P. Gilbert, D. Montefiori, A. McDermott, Y. Fong, D. Benkeser, Wei-zhi Deng, Honghong Zhou, Christopher R. Houchens, Karen Martins, L. Jayashankar, F. Castellino, B. Flach, Bob C. Lin, S. O'connell, C. McDanal, Amanda Eaton, M. Sarzotti-Kelsoe, Yiwen Lu, Chenchen Yu, Bhavesh Borate, Lars van der Laan, N. Hejazi, C. Huynh, Jacqueline Miller, Hana M. El Sahly, L. Baden, Mira Baron, Luis de la Cruz, C. Gay, Spyros A. Kalams, Colleen F. Kelley, M. Andrasik, J. Kublin, L. Corey, K. Neuzil, Lindsay N. Carpp, R. Pajon, D. Follmann, R. Donis, R. Koup   +39 more
semanticscholar   +1 more source

SARS‑CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T-cell immunity in mice

Human Vaccines & Immunotherapeutics, 2021
There is an urgent need for an accessible and low-cost COVID-19 vaccine suitable for low- and middle-income countries. Here, we report on the development of a SARS-CoV-2 receptor-binding domain (RBD) protein, expressed at high levels in yeast (Pichia ...
Jeroen Pollet, Wen-Hsiang Chen, Leroy Versteeg, Brian Keegan, Bin Zhan, Junfei Wei, Zhuyun Liu, Jungsoon Lee, Rahki Kundu, Rakesh Adhikari, Cristina Poveda, Maria Jose Villar, Ana Carolina de Araujo Leao, Joanne Altieri Rivera, Zoha Momin, Portia M. Gillespie, Jason T. Kimata, Ulrich Strych, Peter J. Hotez, Maria Elena Bottazzi   +19 more
doaj   +1 more source

Barriers and facilitators to HPV vaccination in primary care practices: A mixed methods study using the Consolidated Framework for Implementation Research [PDF]

, 2018
Background In the United States, the effective, safe huma papilloma virus (HPV) vaccine is underused and opportunities to prevent cancer continue to be missed.
Dodd, Sherry, Garbutt, Jane M, Kulka, Katharine, Lee, Amanda A, Lobb, Rebecca, Walling, Emily   +5 more
core   +2 more sources

Vaccine hesitancy: Beliefs and barriers associated with COVID‐19 vaccination among Egyptian medical students

Journal of Medical Virology, 2021
Vaccine hesitancy poses serious challenges for achieving coverage for population immunity. It is necessary to achieve high COVID‐19 vaccination acceptance rates and medical students’ coverage as future health care providers.
Shimaa M. Saied, E. Saied, I. Kabbash, Sanaa A Abdo   +3 more
semanticscholar   +1 more source

Immunotherapeutic Potential of CpG Oligonucleotides in Chickens

The Journal of Poultry Science, 2009
Synthetic oligodeoxynucleotides (ODN) containing CpG motifs activate innate and adaptive immune responses in numerous vertebrate species. The protective effects of CpG ODN against viral, bacterial and protozoal pathogens have been well documented in ...
Arshud Dar, Brenda Allan, Susantha Gomis, Andrew Potter, George Mutwiri   +4 more
doaj   +1 more source

COVID-19 vaccine acceptance among pregnant women and mothers of young children: results of a survey in 16 countries

European Journal of Epidemiology, 2021
With the development of multiple effective vaccines, reducing the global morbidity and mortality of COVID-19 will depend on the distribution and acceptance of COVID-19 vaccination.
Malia Skjefte, Michelle Ngirbabul, Oluwasefunmi Akeju, Daniel J Escudero, S. Hernández-Díaz, D. Wyszynski, J. Wu   +6 more
semanticscholar   +1 more source

O-Acetylation is essential for functional antibody generation against Staphylococcus aureus capsular polysaccharide

Human Vaccines & Immunotherapeutics, 2018
Staphylococcus aureus produces an antiphagocytic polysaccharide capsule to evade neutrophil-mediated killing. Many vaccines against encapsulated bacterial pathogens require generation of functional anti-capsular antibodies to mediate protection against ...
Ingrid L. Scully, Viliam Pavliak, Yekaterina Timofeyeva, Yongdong Liu, Christine Singer, Annaliesa S. Anderson   +5 more
doaj   +1 more source