Results 91 to 100 of about 596,848 (310)

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source

Adjuvanted influenza vaccines

Expert Review of Vaccines, 2013
Influenza is one of the most common causes of human morbidity and mortality that is preventable by vaccination. Immunization with available vaccines provides incomplete protection against illness caused by influenza virus, especially in high-risk groups such as the elderly and young children.
Orli, Even-Or, Sarit, Samira, Ronald, Ellis, Eli, Kedar, Yechezkel, Barenholz   +4 more
openaire   +2 more sources

The non-toxic and biodegradable adjuvant Montanide ISA 720/CpG can replace Freund's in a cancer vaccine targeting ED-B—a prerequisite for clinical development

, 2012
We have recently shown that immunization against the extra domain-B (ED-B) of fibronectin, using Freund's adjuvant, reduces tumor growth in mice by 70%.
Andersson, Karl,, Huijbers, Elisabeth J M,, Julia Femel, Lars Hellman, Anna-Karin Olsson, Björkelund, Hanna,, Olsson, Anna-Karin,, Karl Andersson, Elisabeth J.M. Huijbers, Hanna Björkelund, Femel, Julia,, Hellman, Lars,   +11 more
core   +1 more source

Screening vaccine formulations for biological activity using fresh human whole blood. [PDF]

, 2014
Understanding the relevant biological activity of any pharmaceutical formulation destined for human use is crucial. For vaccine-based formulations, activity must reflect the expected immune response, while for non-vaccine therapeutic agents, such as ...
Ha, Yukyung, Rahman, Nausheen, Brookes, Roger H, Aboutorabian, Sepideh, Brookes, Roger, Dockrell, Hazel, Smith, Steven G., Todryk, Stephen, Hasija, Manvi, Todryk, Stephen M, Smith, Steven G, Ausar, Salvador, Ausar, Salvador F, Dockrell, Hazel M, Hakimi, Jalil   +14 more
core   +1 more source

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

Advanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu, Yingyu Zhang, Xianwei Zhang, Mengxin Zhang, Fei Zhang, Jushan Sun, Yahui Yang, Kangbo Liu, Peng Wang, Shuying Luo, Wancun Zhang   +10 more
wiley   +1 more source

Adjuvant-Free COVID-19 Vaccine with Glycoprotein Antigen Oxidized by Periodate Rapidly Elicits Potent Immune Responses

Modification of antigens to improve their immunogenicity represents a promising direction for the development of protein vaccine. Here, we designed facilely prepared adjuvant-free vaccines in which the N-glycan of SARS-CoV-2 receptor-binding domain (RBD)
Ru-Yan Zhang (6443417), Dong Ding (112949), Shi-Hao Zhou (11994123), Hua-Wei Wei (12035969), Zhi-Ming Zhang (33286), Jun Guo (85069), Ran-Ran Feng (12935219), Yu Wen (303123)   +7 more
core   +1 more source

CD8(+) T cell adjuvant effects of Salmonella FliCd flagellin in live vaccine vectors or as purified protein

, 2010
Salmonella flagellin, the flagellum structural subunit, has received particular interest as a vaccine adjuvant conferring enhanced immunogenity to soluble proteins or peptides, both for activation of antibody and cellular immune responses. In the present
Rodrigues, Mauricio M. [UNIFESP], RODRIGUES, Mauricio M., ALENCAR, Bruna C. G., Alencar, Bruna C. G. [UNIFESP], BARGIERI, Daniel Y., Bargieri, Daniel Y. [UNIFESP], Sbrogio-Almeida, Maria E., Boscardin, Silvia B., Braga, Catarina J. M., Massis, Liliana M., Ferreira, Luis C. S., Daniel Y. Bargieri, Liliana M. Massis, Silvia B. Boscardin, Ferreira, Luís Carlos de Souza, Luís C.S. Ferreira, Catarina J.M. Braga, Maria E. Sbrogio-Almeida, Bruna C.G. Alencar, Maurício M. Rodrigues   +19 more
core   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Intranasal immunization of young mice with a multigene HIV-1 vaccine in combination with the N3 adjuvant induces mucosal and systemic immune responses

, 2008
One of the major challenges for the development of an HIV vaccine is to induce potent virus-specific immune responses at the mucosal surfaces where transmission of virus occurs.
Blomberg, Pontus, Pontus Blomberg, Ulf Schröder, Britta Wahren, Wahren, Britta, Andreas Bråve, Hallengärd, David, Hinkula, Jorma,, David Hallengärd, Jorma Hinkula, Bråve, Andreas, Schröder, Ulf, Hallengard, D,, Blomberg, P,, Hinkula, J, Brave, A,, Wahren, B,, Schroder, U   +17 more
core   +1 more source