Results 101 to 110 of about 545,826 (308)

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

A novel technology for the production of a heterologous lipoprotein immunogen in high yield has implications for the field of vaccine design

, 2009
[[abstract]]We have developed a novel platform technology that can express high levels of recombinant lipoproteins with intrinsic adjuvant properties. In this study, Ag473 (a lipoprotein from Neisseria meningitidis) can be produced in high yields using ...
Chen, HW;Liu, SJ;Liu, HH;Kwok, Y;Lin, CL;Lin, LH;Chen, MY;Tsai, JP;Chang, LS;Chiu, FF;Lai, Lw;Lian, WC;Yang, CY;Hsieh, SY;Chong, P;Leng, CH
core   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Evaluation of the immunological responses elicited by the Nigella sativa oil and comparison with Freund's vaccine adjuvant [PDF]

Basrah Journal of Veterinary Research
This study was planned to evaluate the adaptive and innate immune responses by preparing and evaluating the immunizing and protective efficacy of an inactivated whole gram-negative bacteria and their crude antigens with natural adjuvant Nigella sativa (N.
Maysaa A. Jumaah, Ali Iedani
doaj   +1 more source

Safety and immunogenicity of AS03B adjuvanted split virion versus non-adjuvanted whole virion H1N1 influenza vaccine in UK children aged 6 months-12 years: open label, randomised, parallel group, multicentre study [PDF]

, 2010
Objectives: To compare the safety, reactogenicity, and immunogenicity of an adjuvanted split virion H1N1 vaccine and a non-adjuvanted whole virion vaccine used in the pandemic immunisation programme in the United Kingdom.
Sheasby, E, Faust, S N, Okike, I, Miller, E., Casey, M., Walker, W T, Sheasby, E., Waight, P., Ladhani, S., Allen, R.J., Andrews, N, Eccleston, P.E., Faust, S.N., Oeser, C, John, T, Snape, MD, Pollard, AJ, Pollard, Andrew, Finn, A., Casey, M, Waddington, CS, Heath, PT, Heath, P.T., Collinson, AC, Eccleston, P E, Waddington, Claire S, Wilkins, S, Allen, R J, Faust, SN, Walker, W.T., Reiner, A, Ladhani, S, Collinson, A.C., Okike, I., Reiner, A., Waddington, Claire S., Miller, E, Andrews, N., Allen, RJ, Finn, A, Wilkins, S., Snape, M.D., Pollard, A.J., Eccleston, PE, Collinson, A C, Walker, WT, Heath, P T, Snape, M D, Hoschler, K., John, T., Hoschler, K, Waight, P, Oeser, C.   +52 more
core   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Radiation‐Triggered Chemokine‐Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy

Advanced Science, EarlyView.
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu, Yuzhong Qian, Shaobo Huang, Bingbing Li, Yue Yu, Xiang Cheng, Chang Chen, Jiheng Wang, Maosong Yang, Lizheng Liang, Xiancai Meng, Zhigang Liu   +11 more
wiley   +1 more source

Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis

, 2020
Tuberculosis still claims more lives than any other pathogen, and a vaccine better than BCG is urgently needed. One of the challenges for novel TB vaccines is to protect against all Mycobacterium tuberculosis lineages, including the most virulent ones ...
권기웅, 신성재
core   +1 more source

Non‐Invasively Quantitative Raman Imaging for Calculation of Lymphatic Transport Kinetics of Micelles in Mice

Advanced Science, EarlyView.
Non‐invasively quantitative Raman imaging with stacking‐induced charge transfer‐enhanced Raman scattering (SICTERS) enables accurate measurement of concentrations and pharmacokinetic modeling of lymphatic transport of micelles in mice. This platform allows dynamic analysis of nanoparticle transport and underpins the design of effective lymph node ...
Yunlu Li, Hongzheng Lin, Sheng Yu, Yunhui Liao, Teng Huang, Zeyu Xiao, Wei Lu   +6 more
wiley   +1 more source

Spherical particles derived from TMV virions enhance the protective properties of the rabies vaccine

Data in Brief, 2018
In this study the ability of spherical particles (SPs) obtained from the tobacco mosaic virus (TMV) virions to enhance the immunogenic potential of the vaccine was evaluated.
N.A. Nikitin, I.N. Matveeva, E.A. Trifonova, N.M. Puhova, A. Ya Samuylenko, S.A. Gryn, J.G. Atabekov, O.V. Karpova   +7 more
doaj   +1 more source