Results 141 to 150 of about 15,392,732 (265)

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Searching for immune correlates in Lassa vaccine development - workshop report. [PDF]

NPJ Vaccines
Brasel T, Brangel P, Adetifa I, Baize S, Benkeser D, Bertoletti A, Bukreyev A, Charlton S, Cramer J, Cross RW, Davenport MP, Emperador D, Formenty P, Follmann D, Garry RF, Gilbert PB, Gilbert SC, Gollihar JD, Grassly NC, Gruber M, Gupta SB, Günther S, Hacker A, Hoath C, Holbrook MR, Killip M, King D, Mandi H, Munster VJ, Mukandavire C, Oestereich L, Okogbenin S, Oloo P, Paessler S, Plotkin S, Richert L, Safronetz D, Saphire EO, Sette A, Shurtleff A, Granerod J, Wohl D, Zaric M, Ramsauer K, Dahlke C.   +44 more
europepmc   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Immune Mechanisms and Translational Study Design in Viral Vaccine Development. [PDF]

Int J Mol Sci
Lim S, Martina B.
europepmc   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

Reinfection as a central constraint on tuberculosis vaccine development. [PDF]

Front Immunol
Cardona PJ.
europepmc   +1 more source

Immunotherapy and Vaccine Development

Journal of Immunology Research, 2018
Leung, Carol, Münz, Christian, Riemer, Angelika   +2 more
openaire   +5 more sources

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Bridging the gap: the Pasteur Network's approach to equitable vaccine development and manufacturing. [PDF]

BMC Glob Public Health
Pasteur Network Vaccine Manufacturing Initiative.
europepmc   +1 more source

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source