Results 241 to 250 of about 435,241 (348)

Local Specific IgE Levels Can Predict and Monitor the Therapeutic Response to Subcutaneous Immunotherapy With House Dust Mite

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Identifying predictive and monitoring biomarkers for allergen immunotherapy response is crucial for enhancing clinical efficacy. This study aims to investigate the systemic and local levels of immunoglobulins and identify potential biomarkers in house dust mite (HDM) allergic rhinitis (AR) patients who are undergoing subcutaneous ...
Xu Xu, Jingyun Li, Xu Zhang, Yu Song, Lin Xi, Luo Zhang, Yuan Zhang   +6 more
wiley   +1 more source

Immunomodulatory effects of gut microbiota on vaccine efficacy against respiratory pathogens. [PDF]

Front Immunol
Xue L, Wang C, Liu C.
europepmc   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Comparative Field Efficacy of Live Infectious Bursal Disease and HVT-IBD Vector Vaccines against the Egyptian Variant Strain A2dB1

Khalid Nabieh, Ali Zanaty, Mona Badr, Karim Selim, Mohamed M. Hamoud, Magdy F. El-Kady, Ahmed Abd El-Samie Ali, Kareem E. Hassan   +7 more
openalex   +1 more source

Immune correlates analysis of mRNA-1345 RSV vaccine efficacy clinical trial. [PDF]

Nat Commun
Ma C, Du J, Lan L, Kapoor A, Marc GP, Jimenez G, Duncan CJA, Le Cam N, Lin N, Priddy F, Garg S, Stoszek SK, Shaw CA, Goswami J, Wilson E, Das R, Zhou H, Zheng L.   +17 more
europepmc   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Single-cell transcriptomics uncovers key immune drivers of vaccine efficacy in cattle. [PDF]

BMC Genomics
Wilson A, Alexandre PA, Brice AM, Hine BC, Ingham A, Legrand TPRA, Royle C, Niemeyer D, Reverter A, Denman SE, Farr RJ.   +10 more
europepmc   +1 more source

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source

LPS/TLR4-activated M1-polarized macrophage-derived exosomes enhance IBV vaccine efficacy in chickens. [PDF]

J Virol
Zhou J, Cai S, Huang H, Yang F, Pan K, Sun Z, Fan Y, Wen F, Qin L, Zhang Y.   +9 more
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source