Results 31 to 40 of about 2,076,500 (256)

The public health impact of malaria vaccine RTS,S in malaria endemic Africa: country-specific predictions using 18 month follow-up Phase III data and simulation models [PDF]

, 2015
The RTS,S/AS01 malaria vaccine candidate recently completed Phase III trials in 11 African sites. Recommendations for its deployment will partly depend on predictions of public health impact in endemic countries.
Katya Galactionova, Marcel Tanner, Michael Tarantino, Melissa A Penny, Smith, Thomas A., Galactionova, Katya, Tarantino, Michael, Thomas A Smith, Penny, Melissa A., Tanner, Marcel   +9 more
core   +1 more source

Modelling population-level impact to inform target product profiles for childhood malaria vaccines

BMC Medicine, 2018
Background The RTS,S/AS01 vaccine for Plasmodium falciparum malaria demonstrated moderate efficacy in 5–17-month-old children in phase 3 trials, and from 2018, the vaccine will be evaluated through a large-scale pilot implementation program.
Alexandra B. Hogan, Peter Winskill, Robert Verity, Jamie T. Griffin, Azra C. Ghani   +4 more
doaj   +1 more source

Vaccination of risk groups in England using the 13 valent pneumococcal conjugate vaccine: economic analysis. [PDF]

, 2012
OBJECTIVE: To estimate the cost effectiveness of vaccinating people with high risk conditions against invasive pneumococcal disease using the 13 valent pneumococcal conjugate vaccine.
Edmunds, W. John, van Hoek, Albert Jan, Trotter, Caroline L, Rozenbaum, Mark H., C. L. Trotter, Miller, Elizabeth, Rozenbaum, Mark H, D. Fleming, Trotter, Caroline L., E. Miller, M. H. Rozenbaum, Edmunds, W John, W. J. Edmunds, Fleming, Douglas, A. J. van Hoek   +14 more
core   +2 more sources

Preliminary Study on the Efficacy of a Recombinant, Subunit SARS-CoV-2 Animal Vaccine against Virulent SARS-CoV-2 Challenge in Cats

, 2023
The objective of this work was to evaluate the safety and efficacy of a recombinant, subunit SARS-CoV-2 animal vaccine in cats against virulent SARS-CoV-2 challenge.
Jason Millership, Igor Morozov, Jamie Retallick, Chester McDowell, Bianca Libanori Artiaga, David A. Meekins, Kendra Hutchinson, Daniel W. Madden, Vickie King, Taeyong Kwon, Denise J. Schwahn, John M. Hardham, Bradley Njaa, Natasha N. Gaudreault, George Tkalcevic, William C. Wilson, Sabarish V. Indran, Hanne Vander Horst, Mahesh Kumar, Jessie D. Trujillo, Konner Cool, Juergen A. Richt, Velmurugan Balaraman, Nicole Hainer, Yulia Burakova   +24 more
core   +1 more source

Global estimates of rotavirus vaccine efficacy and effectiveness: a rapid review and meta-regression analysisResearch in context

EClinicalMedicine
Summary: Background: Rotavirus is the leading cause of diarrhoea worldwide, particularly affecting young children. While national rotavirus immunization programs have reduced rotavirus morbidity and mortality, vaccine performance varies considerably ...
Ottavia Prunas, Ernest O. Asare, Elizabeth Sajewski, Yueqi Li, Zeaan Pithawala, Daniel M. Weinberger, Joshua L. Warren, George E. Armah, Nigel A. Cunliffe, Miren Iturriza-Gómara, Benjamin A. Lopman, Virginia E. Pitzer   +11 more
doaj   +1 more source

Malaria vaccine research and development: the role of the WHO MALVAC committee. [PDF]

, 2013
The WHO Malaria Vaccine Advisory Committee (MALVAC) provides advice to WHO on strategic priorities, activities and technical issues related to global efforts to develop vaccines against malaria.
Vasee S Moorthy, Graham V Brown, Geoffrey AT Targett, Targett, Geoffrey AT, Brown, GV, Moorthy, Vasee S, Brown, Graham V, Geoffrey AT Targett, Moorthy, VS, Targett, GA   +9 more
core   +1 more source

Sieve analysis of breakthrough HIV-1 sequences in HVTN 505 identifies vaccine pressure targeting the CD4 binding site of Env-gp120. [PDF]

PLoS ONE, 2017
Although the HVTN 505 DNA/recombinant adenovirus type 5 vector HIV-1 vaccine trial showed no overall efficacy, analysis of breakthrough HIV-1 sequences in participants can help determine whether vaccine-induced immune responses impacted viruses that ...
Allan C deCamp, Morgane Rolland, Paul T Edlefsen, Eric Sanders-Buell, Breana Hall, Craig A Magaret, Andrew J Fiore-Gartland, Michal Juraska, Lindsay N Carpp, Shelly T Karuna, Meera Bose, Steven LePore, Shana Miller, Annemarie O'Sullivan, Kultida Poltavee, Hongjun Bai, Kalpana Dommaraju, Hong Zhao, Kim Wong, Lennie Chen, Hasan Ahmed, Derrick Goodman, Matthew Z Tay, Raphael Gottardo, Richard A Koup, Robert Bailer, John R Mascola, Barney S Graham, Mario Roederer, Robert J O'Connell, Nelson L Michael, Merlin L Robb, Elizabeth Adams, Patricia D'Souza, James Kublin, Lawrence Corey, Daniel E Geraghty, Nicole Frahm, Georgia D Tomaras, M Juliana McElrath, Lisa Frenkel, Sheila Styrchak, Sodsai Tovanabutra, Magdalena E Sobieszczyk, Scott M Hammer, Jerome H Kim, James I Mullins, Peter B Gilbert   +47 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epidemiological assessment of vaccine efficacy [PDF]

Veterinary World, 2009
The success of an epidemiological program against infectious diseases depends on an effective prophylactic vaccine. Although efficacy and effectiveness are used interchangeably, effectiveness depends upon efficacy.
G.V. Asokan
doaj  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source